ArticleNeurobiology of aging2013
Development of amyloid burden in African Green monkeys.
Article in Neurobiology of aging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 34 citations in OpenAlex.
- Physiological IgM class catalytic antibodies selective for transthyretin amyloid.The Journal of biological chemistry · 2014Trial
- Neuropathology and Biomarker Correlates of Late Onset Alzheimer's Disease in Aged Old World Monkeys.Toxicologic pathology · 2025Review
- African Green Monkeys Respond to Synthetic Aβ Oligomers with Persistent Alzheimer's-like Activation.bioRxiv : the preprint server for biology · 2025Article
- Effects of Diminished Cerebrospinal Fluid Flow in the Spinal Canal on Amyloid Pathophysiology in Vervet Monkeys.Research square · 2025Article
- The neuropathologic basis for translational biomarker development in the macaque model of late-onset Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2025Article
- Exploratory Dual PET imaging of [Bioorganic & medicinal chemistry letters · 2024Article
- Intrathecal amyloid-beta oligomer administration increases tau phosphorylation in the medial temporal lobe in the African green monkey: A nonhuman primate model of Alzheimer's disease.Neuropathology and applied neurobiology · 2022Article
- Epigenetic clock and methylation studies in vervet monkeys.GeroScience · 2022Article
- Transcriptional profiles in olfactory pathway-associated brain regions of African green monkeys: Associations with age and Alzheimer's disease neuropathology.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Characterization of cerebrospinal fluid biomarkers associated with neurodegenerative diseases in healthy cynomolgus and rhesus macaque monkeys.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet.BMC genomics · 2021Article
- Aging-related Alzheimer's disease-like neuropathology and functional decline in captive vervet monkeys (Chlorocebus aethiops sabaeus).American journal of primatology · 2021Review
- Comparative neuropathology in aging primates: A perspective.American journal of primatology · 2021Review
- Review
- Stress and Alzheimer's disease: A senescence link?Neuroscience and biobehavioral reviews · 2020Review
- Translational animal models for Alzheimer's disease: An Alzheimer's Association Business Consortium Think Tank.Alzheimer's & dementia (New York, N. Y.) · 2020Article
- Granulovacuolar Degeneration in Brains of Senile Cynomolgus Monkeys.Frontiers in aging neuroscience · 2019Article
- Effects of Reducing Norepinephrine Levels via DSP4 Treatment on Amyloid-β Pathology in Female Rhesus Macaques (Macaca Mulatta).Journal of Alzheimer's disease : JAD · 2019Article
- A nonhuman primate model of early Alzheimer's disease pathologic change: Implications for disease pathogenesis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019Article
- Type-2-Diabetes Alters CSF but Not Plasma Metabolomic and AD Risk Profiles in Vervet Monkeys.Frontiers in neuroscience · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The vervet is an old world monkey increasingly being used as a model for human diseases. In addition to plaques and tangles, an additional hallmark of Alzheimer's disease is damage to neurons that synthesize noradrenaline (NA). We characterized amyloid burden in the posterior temporal lobe of young and aged vervets, and compared that with changes in NA levels and astrocyte activation. Total amyloid beta (Aβ)40 and Aβ42 levels were increased in the aged group, as were numbers of amyloid plaques detected using antibody 6E10. Low levels of Aβ42 were detected in 1 of 5 younger animals, although diffusely stained plaques were observed in 4 of these. Increased glial fibrillary acidic protein staining and messenger RNA levels were significantly correlated with increased age, as were cortical NA levels. Levels of Aβ42 and Aβ40, and the number of 6E10-positive plaques, were correlated with NA levels. Interestingly messenger RNA levels of glial derived neurotrophic factor, important for noradrenergic neuronal survival, were reduced with age. These findings suggest that amyloid pathology in aged vervets is associated with astrocyte activation and higher NA levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.