ArticleImmunity2013
Nkx2-5(+)islet1(+) mesenchymal precursors generate distinct spleen stromal cell subsets and participate in restoring stromal network integrity.
Article in Immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 90 citations in OpenAlex.
- Compartment-specific regulation of stromal differentiation of the spleen in health and disease.Genes and immunity · 2026Review
- Understanding development and cellular plasticity in the pancreas in health and disease.Nature reviews. Gastroenterology & hepatology · 2026Review
- Cancer-associated fibroblasts and tertiary lymphoid structure orchestrate the spatial architecture of tumor immunity.Journal of hematology & oncology · 2026Review
- Mesenchymal stromal cells counteract with age-related immune decline and enhance vaccine efficacy by modulating endogenous splenic marginal reticular cells in elderly models.Cellular & molecular immunology · 2026Article
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- Pancreatic organogenesis mapped through space and time.Experimental & molecular medicine · 2025Article
- Fibroblast heterogeneity and its role in generating protective immunity in the secondary lymphoid organs.Frontiers in immunology · 2025Review
- Protective fibroblastic niches in secondary lymphoid organs.The Journal of experimental medicine · 2024Review
- Hematopoiesis in the spleen after engraftment in unrelated cord blood transplantation evaluated byInternational journal of hematology · 2023Article
- Article
- The small and large intestine contain related mesenchymal subsets that derive from embryonic Gli1Nature communications · 2023Article
- Skeletal stem/progenitor cells provide the niche for extramedullary hematopoiesis in spleen.Frontiers in physiology · 2023Article
- NestinInternational journal of molecular sciences · 2022Article
- Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis.Frontiers in medicine · 2022Article
- Development of follicular dendritic cells in lymph nodes depends on retinoic acid-mediated signaling.Development (Cambridge, England) · 2021Article
- A human cell atlas of fetal gene expression.Science (New York, N.Y.) · 2020Article
- A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation.Developmental cell · 2020Article
- Lymph node stromal cells: cartographers of the immune system.Nature immunology · 2020Review
- Transcription factor Tlx1 marks a subset of lymphoid tissue organizer-like mesenchymal progenitor cells in the neonatal spleen.Scientific reports · 2019Article
- Embryonic FAPThe Journal of experimental medicine · 2019Article
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12 authors at 6 institutions in 3 countries.
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Abstract
Secondary lymphoid organ stromal cells comprise different subsets whose origins remain unknown. Herein, we exploit a genetic lineage-tracing approach to show that splenic fibroblastic reticular cells (FRCs), follicular dendritic cells (FDCs), marginal reticular cells (MRCs), and mural cells, but not endothelial cells, originate from embryonic mesenchymal progenitors of the Nkx2-5(+)Islet1(+) lineage. This lineage include embryonic mesenchymal cells with lymphoid tissue organizer (LTo) activity capable also of supporting ectopic lymphoid-like structures and a subset of resident spleen stromal cells that proliferate and regenerate the splenic stromal microenvironment following resolution of a viral infection. These findings identify progenitor cells that generate stromal diversity in spleen development and repair and suggest the existence of multipotent stromal progenitors in the adult spleen with regenerative capacity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.