Evidence map›Paper›PMID 23601662›Full record

ArticleBiomaterials2013

Mimicking white matter tract topography using core-shell electrospun nanofibers to examine migration of malignant brain tumors.

Shreyas S Rao, Mark T Nelson, Ruipeng Xue, Jessica K DeJesus, Mariano S Viapiano, John J Lannutti, Atom Sarkar, Jessica O Winter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.

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  18. In vitro contact guidance of glioblastoma cells on metallic biomaterials.Journal of materials science. Materials in medicine · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Shreyas S RaoWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA.
Mark T Nelson
Ruipeng Xue
Jessica K DeJesus
Mariano S Viapiano
John J Lannutti
Atom Sarkar
Jessica O Winter
The Ohio State University · USGeisinger Health System · US

Funding

The Ohio State University Center for clinical and Translational ScienceUL1TR001070 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$22.6M
Targeting the Tumor Matrix as Anti-Invasive and Sensitizing Strategy for GliomaR01CA152065 · NCI · OHIO STATE UNIVERSITY · PI VIAPIANO, MARIANO SEBASTIAN · 2010 to 2014
$1.3M
NCATS NIH HHS UL1 TR001070NCI NIH HHS R01 CA152065
6 · The paper itself

Abstract

Glioblastoma multiforme (GBM), one of the deadliest forms of human cancer, is characterized by its high infiltration capacity, partially regulated by the neural extracellular matrix (ECM). A major limitation in developing effective treatments is the lack of in vitro models that mimic features of GBM migration highways. Ideally, these models would permit tunable control of mechanics and chemistry to allow the unique role of each of these components to be examined. To address this need, we developed aligned nanofiber biomaterials via core-shell electrospinning that permit systematic study of mechanical and chemical influences on cell adhesion and migration. These models mimic the topography of white matter tracts, a major GBM migration 'highway'. To independently investigate the influence of chemistry and mechanics on GBM behaviors, nanofiber mechanics were modulated by using different polymers (i.e., gelatin, poly(ethersulfone), poly(dimethylsiloxane)) in the 'core' while employing a common poly(ε-caprolactone) (PCL) 'shell' to conserve surface chemistry. These materials revealed GBM sensitivity to nanofiber mechanics, with single cell morphology (Feret diameter), migration speed, focal adhesion kinase (FAK) and myosin light chain 2 (MLC2) expression all showing a strong dependence on nanofiber modulus. Similarly, modulating nanofiber chemistry using extracellular matrix molecules (i.e., hyaluronic acid (HA), collagen, and Matrigel) in the 'shell' material with a common PCL 'core' to conserve mechanical properties revealed GBM sensitivity to HA; specifically, a negative effect on migration. This system, which mimics the topographical features of white matter tracts, should allow further examination of the complex interplay of mechanics, chemistry, and topography in regulating brain tumor behaviors.

Indexed as

Cell MovementBlotting, WesternBrainBrain NeoplasmsCardiac MyosinsCell AdhesionCell ShapeDimethylpolysiloxanesFocal Adhesion Protein-Tyrosine KinasesGlioblastomaHumansMechanical PhenomenaMyosin Light ChainsNanofibersPolyestersCardiac MyosinsDimethylpolysiloxanesFocal Adhesion Protein-Tyrosine Kinasesmyosin light chain 2Myosin Light ChainspolycaprolactonePolyesters

Identifiers

PMID23601662
PMCPMC4080638
OpenAlexW1964467566

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.