ReviewCurrent opinion in microbiology2013
Beyond the cytoskeleton: mesoscale assemblies and their function in spatial organization.
Review in Current opinion in microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Mechanistic insights into condensate formation of human liver-type phosphofructokinase by stochastic modeling approaches.Scientific reports · 2024Article
- Effects of A6E Mutation on Protein Expression and Supramolecular Assembly of Yeast Asparagine Synthetase.Biology · 2021Article
- Article
- Regulation of reaction fluxes via enzyme sequestration and co-clustering.Journal of the Royal Society, Interface · 2019Article
- Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Regulation of Cellular Metabolism through Phase Separation of Enzymes.Biomolecules · 2018Review
- Spatial Organization of Metabolic Enzyme Complexes in Cells.Biochemistry · 2017Review
- Colocalization and Sequential Enzyme Activity in Aqueous Biphasic Systems: Experiments and Modeling.Biophysical journal · 2015Article
- Purinosome formation as a function of the cell cycle.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Dynamic architecture of the purinosome involved in human de novo purine biosynthesis.Biochemistry · 2015Article
- A stress assembly that confers cell viability by preserving ERES components during amino-acid starvation.eLife · 2014Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Recent studies have identified a growing number of mesoscale protein assemblies in both bacterial and eukaryotic cells. Traditionally, these polymeric assemblies are thought to provide structural support for the cell and thus have been classified as the cytoskeleton. However a new class of macromolecular structure is emerging as an organizer of cellular processes that occur on scales hundreds of times larger than a single protein. We propose two types of self-assembling structures, dynamic globules and crystalline scaffolds, and suggest they provide a means to achieve cell-scale order. We discuss general mechanisms for assembly and regulation. Finally, we discuss assemblies that are found to organize metabolism and what possible mechanisms may serve these metabolic enzyme complexes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.