ArticleBiophysical journal2013
Cellular compartments cause multistability and allow cells to process more information.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 57 citations in OpenAlex.
- Retinoic Acid Receptor γ Is a Ligand-Activated Gatekeeper to Stem Cell Developmental Progression.International journal of molecular sciences · 2026Review
- Cell Lineage Affiliation During Hematopoiesis.International journal of molecular sciences · 2025Review
- Compartmental exchange regulates steady states and stochastic switching of a phosphorylation network.Biophysical journal · 2024Article
- Julia for biologists.Nature methods · 2023Review
- Hematopoietic and Chronic Myeloid Leukemia Stem Cells: Multi-Stability versus Lineage Restriction.International journal of molecular sciences · 2022Review
- A robust method for designing multistable systems by embedding bistable subsystems.NPJ systems biology and applications · 2022Article
- WHIRLY1 functions in the nucleus to regulate barley leaf development and associated metabolite profiles.The Biochemical journal · 2022Article
- Central Metabolism in Mammals and Plants as a Hub for Controlling Cell Fate.Antioxidants & redox signaling · 2021Review
- Dynamic bistable switches enhance robustness and accuracy of cell cycle transitions.PLoS computational biology · 2021Article
- Resolving subcellular plant metabolism.The Plant journal : for cell and molecular biology · 2019Article
- A multiscale model of epigenetic heterogeneity-driven cell fate decision-making.PLoS computational biology · 2019Article
- Enzyme sequestration by the substrate: An analysis in the deterministic and stochastic domains.PLoS computational biology · 2018Article
- Dynamics of Posttranslational Modification Systems: Recent Progress and Future Directions.Biophysical journal · 2018Review
- The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt.PLoS computational biology · 2017Article
- The effect of site-to-site variability in ultrasensitive dose responses.Journal of mathematical biology · 2017Article
- Core signalling motif displaying multistability through multi-state enzymes.Journal of the Royal Society, Interface · 2016Article
- Long-term dynamics of multisite phosphorylation.Molecular biology of the cell · 2016Article
- Robustness of MEK-ERK Dynamics and Origins of Cell-to-Cell Variability in MAPK Signaling.Cell reports · 2016Article
- Spatial Control of Biochemical Modification Cascades and Pathways.Biophysical journal · 2015Article
- Finding the positive feedback loops underlying multi-stationarity.BMC systems biology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Many biological, physical, and social interactions have a particular dependence on where they take place; e.g., in living cells, protein movement between the nucleus and cytoplasm affects cellular responses (i.e., proteins must be present in the nucleus to regulate their target genes). Here we use recent developments from dynamical systems and chemical reaction network theory to identify and characterize the key-role of the spatial organization of eukaryotic cells in cellular information processing. In particular, the existence of distinct compartments plays a pivotal role in whether a system is capable of multistationarity (multiple response states), and is thus directly linked to the amount of information that the signaling molecules can represent in the nucleus. Multistationarity provides a mechanism for switching between different response states in cell signaling systems and enables multiple outcomes for cellular-decision making. We combine different mathematical techniques to provide a heuristic procedure to determine if a system has the capacity for multiple steady states, and find conditions that ensure that multiple steady states cannot occur. Notably, we find that introducing species localization can alter the capacity for multistationarity, and we mathematically demonstrate that shuttling confers flexibility for and greater control of the emergence of an all-or-nothing response of a cell.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.