ArticleBiophysical journal2013
Regulating the many to benefit the few: role of weak small RNA targets.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Codon bias shapes bacterial small RNA binding sites within protein-coding sequences.RNA (New York, N.Y.) · 2026Article
- Beyond the heat shock pathway: Heat stress responses in Drosophila development.Developmental biology · 2025Review
- Kinetic modeling reveals additional regulation at co-transcriptional level by post-transcriptional sRNA regulators.Cell reports · 2021Article
- Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation.eLife · 2020Article
- Hierarchy in Hfq Chaperon Occupancy of Small RNA Targets Plays a Major Role in Their Regulation.Cell reports · 2020Article
- New aspects of RNA-based regulation by Hfq and its partner sRNAs.Current opinion in microbiology · 2018Review
- Identification of competing endogenous RNAs of the tumor suppressor gene PTEN: A probabilistic approach.Scientific reports · 2017Article
- Transcript degradation and noise of small RNA-controlled genes in a switch activated network in Escherichia coli.Nucleic acids research · 2016Article
- Exploring the Dynamics and Mutational Landscape of Riboregulation with a Minimal Synthetic Circuit in Living Cells.Biophysical journal · 2015Article
- Optimal census by quorum sensing.PLoS computational biology · 2015Article
- RNA biochemistry. Determination of in vivo target search kinetics of regulatory noncoding RNA.Science (New York, N.Y.) · 2015Article
- Small regulatory RNA-induced growth rate heterogeneity of Bacillus subtilis.PLoS genetics · 2015Article
- The shock absorber: preventing sRNA transcriptional noise.Cell cycle (Georgetown, Tex.) · 2015Article
- Quantitative effect of target translation on small RNA efficacy reveals a novel mode of interaction.Nucleic acids research · 2014Article
- Exploring the miRNA regulatory network using evolutionary correlations.PLoS computational biology · 2014Article
- Interactions between distant ceRNAs in regulatory networks.Biophysical journal · 2014Article
- Noise and information transmission in promoters with multiple internal States.Biophysical journal · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small regulatory RNAs are central players in the regulation of many cellular processes across all kingdoms of life. Experiments in mouse and human have shown that a typical small RNA may regulate the expression of many different genes, suggesting that small RNAs act as global regulators. It is noted though that most targets respond only weakly to the presence of the small RNA. At the same time, evidence in bacteria and animals suggest that the phenotypes associated with small RNA mutants are only due to a few of their targets. Here we assume that targets regulated by a small RNA to control function is in fact small, and propose that the role of the many other weak targets is to confer robustness to the regulation of these few principal targets. Through mathematical modeling we show that auxiliary targets may significantly buffer both number and kinetic fluctuations of the principal targets, with only minor slowdown in the kinetics of response. Analysis of genomic data suggests that auxiliary targets experience a nonspecific evolutionary pressure, playing a role at the system level. Our work is of importance for studies on small RNA functions, and impacts on the understanding of small RNA evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.