ArticleBiophysical journal2013
Improved ligand discrimination by force-induced unbinding of the T cell receptor from peptide-MHC.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Close Contacts Unlocked: Nanopore-Stabilized Microvilli Bypass T Cell Receptor-Ligand-Dependent T Cell Activation.ACS nano · 2026Article
- Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens.The EMBO journal · 2026Article
- Antigen mobility regulates the dynamics and precision of antigen capture in the B cell immune synapse.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mechanical force matters in early T cell activation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Mechanical control of antigen detection and discrimination by T and B cell receptors.Biophysical journal · 2024Review
- Measurement of Forces Acting on Single T-Cell Receptors.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Smart probes for optical imaging of T cells and screening of anti-cancer immunotherapies.Chemical Society reviews · 2023Review
- T-cell antigen recognition: catch-as-catch-can or catch-22?The EMBO journal · 2023Article
- Understanding How Cells Probe the World: A Preliminary Step towards Modeling Cell Behavior?International journal of molecular sciences · 2023Article
- Understanding immune signaling using advanced imaging techniques.Biochemical Society transactions · 2022Review
- Mechanotransduction as a major driver of cell behaviour: mechanisms, and relevance to cell organization and future research.Open biology · 2021Review
- Temporal analysis of T-cell receptor-imposed forces via quantitative single molecule FRET measurements.Nature communications · 2021Article
- Cooperative Stabilization of Close-Contact Zones Leads to Sensitivity and Selectivity in T-Cell Recognition.Cells · 2021Article
- How drag sharpens a T cell's view on antigen.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- TCR-pMHC kinetics under force in a cell-free system show no intrinsic catch bond, but a minimal encounter duration before binding.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Cytoskeletal Control of Antigen-Dependent T Cell Activation.Cell reports · 2019Article
- TCRs are randomly distributed on the plasma membrane of resting antigen-experienced T cells.Nature immunology · 2018Article
- The cellular environment regulates in situ kinetics of T-cell receptor interaction with peptide major histocompatibility complex.European journal of immunology · 2015Article
- T lymphocytes need less than 3 min to discriminate between peptide MHCs with similar TCR-binding parameters.European journal of immunology · 2015Article
- Mechanical regulation of T-cell functions.Immunological reviews · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T cell activation is mediated via the recognition of peptides by the T cell receptor (TCR). This receptor ligand interaction is highly specific, and the TCR has to discriminate between a huge number of peptides presented by the products of the major histocompatibility complexes (MHCs). Recent studies indicate that cells probe the TCR-pMHC interaction by imposing force on the interaction. Here we investigated in a theoretical analysis the consequences of such force-induced unbinding for T cell recognition. Our findings are as follows. First, the bond rupture under force is much faster, improving the time resolution of the discrimination process. Second, cells can access additional parameters characterizing the shape of the binding energy surface. Third, load-induced unbinding yields a reduced coefficient of variation of the bond lifetimes, which improves the discriminative power even between peptide/MHCs (pMHCs) with similar off-rates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.