ArticleBiophysical journal2013
Anomalous diffusion of single particles in cytoplasm.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Clustering within a single-component biomolecular condensate.bioRxiv : the preprint server for biology · 2025Article
- Review
- Trajectory Analysis in Single-Particle Tracking: From Mean Squared Displacement to Machine Learning Approaches.International journal of molecular sciences · 2024Review
- Review
- Article
- Exploring non-equilibrium processes and spatio-temporal scaling laws in heated egg yolk using coherent X-rays.Nature communications · 2023Article
- Size- and position-dependent cytoplasm viscoelasticity through hydrodynamic interactions with the cell surface.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The Fokker-Planck equation of the superstatistical fractional Brownian motion with application to passive tracers inside cytoplasm.Royal Society open science · 2022Article
- A theoretical study on the effects of interdomain flexibility on drug encounter rate for coronavirus nucleocapsid-type proteins.Biophysical chemistry · 2021Article
- Subtle changes in crosslinking drive diverse anomalous transport characteristics in actin-microtubule networks.Soft matter · 2021Article
- Enhanced diffusion by reversible binding to active polymers.Macromolecules · 2021Article
- Filament Rigidity Vies with Mesh Size in Determining Anomalous Diffusion in Cytoskeleton.Biomacromolecules · 2019Article
- Topology-dependent anomalous dynamics of ring and linear DNA are sensitive to cytoskeleton crosslinking.Science advances · 2019Article
- Damped White Noise Diffusion with Memory for Diffusing Microprobes in Ageing Fibrin Gels.Biophysical journal · 2019Article
- Controlling Anomalous Diffusion in Lipid Membranes.Biophysical journal · 2019Article
- Bridging the spatiotemporal scales of macromolecular transport in crowded biomimetic systems.Soft matter · 2019Article
- Urea-mediated anomalous diffusion in supported lipid bilayers.Interface focus · 2018Article
- Non-specific interactions govern cytosolic diffusion of nanosized objects in mammalian cells.Nature materials · 2018Article
- Langevin equation in complex media and anomalous diffusion.Journal of the Royal Society, Interface · 2018Article
- Do Skeletal Dynamics Mediate Sugar Uptake and Transport in Human Erythrocytes?Biophysical journal · 2018Article
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Authors and funding
7 authors.
Funding
Abstract
The crowded intracellular environment poses a formidable challenge to experimental and theoretical analyses of intracellular transport mechanisms. Our measurements of single-particle trajectories in cytoplasm and their random-walk interpretations elucidate two of these mechanisms: molecular diffusion in crowded environments and cytoskeletal transport along microtubules. We employed acousto-optic deflector microscopy to map out the three-dimensional trajectories of microspheres migrating in the cytosolic fraction of a cellular extract. Classical Brownian motion (BM), continuous time random walk, and fractional BM were alternatively used to represent these trajectories. The comparison of the experimental and numerical data demonstrates that cytoskeletal transport along microtubules and diffusion in the cytosolic fraction exhibit anomalous (nonFickian) behavior and posses statistically distinct signatures. Among the three random-walk models used, continuous time random walk provides the best representation of diffusion, whereas microtubular transport is accurately modeled with fractional BM.
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