ArticleZhongguo fei ai za zhi = Chinese journal of lung cancer2013
[Tumor-stroma ratio is an independent prognostic factor of non-small cell lung cancer].
Article in Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Predictive Role of Tumor-Stroma Ratio for Survival of Patients With Non-Small Cell Lung Cancer: A Meta-Analysis.Pathology oncology research : POR · 2021Pooled it
- Association between tumor-stroma ratio and prognosis in solid tumor patients: a systematic review and meta-analysis.Oncotarget · 2016Pooled it
- Critical role of spread through air spaces in prognosis of stage IA3 non-small cell lung cancer: insights from a real-world multicenter study.Journal of thoracic disease · 2025Article
- Tumor-Stroma Ratio in Colorectal Cancer-Comparison between Human Estimation and Automated Assessment.Cancers · 2023Article
- Standardization of the tumor-stroma ratio scoring method for breast cancer research.Breast cancer research and treatment · 2022Review
- Computer aided quantification of intratumoral stroma yields an independent prognosticator in rectal cancer.Cellular oncology (Dordrecht, Netherlands) · 2019Article
- The prognostic value of tumour-stroma ratio in primary breast cancer with special attention to triple-negative tumours: a review.Breast cancer research and treatment · 2019Review
- Scoring the tumor-stroma ratio in colon cancer: procedure and recommendations.Virchows Archiv : an international journal of pathology · 2018Article
- Comment on: The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer.British journal of cancer · 2015Article
- Standardized Assessment of the Tumor-Stroma Ratio in Colorectal Cancer: Interobserver Validation and Reproducibility of a Potential Prognostic Factor.Clinical pathology (Thousand Oaks, Ventura County, Calif.)Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe different expression of tumor-stroma ratio (TSR) have been proved to be a new and reliable independent prognostic factor in some solid tumors.The aim of the study is to test the different expression of TSR and its prognostic significance in non-small cell lung cancer (NSCLC).
methodsA total of 73 patients who underwent surgery resection for NSCLC were included in this study. TSR was assessed visually on the hematoxylin-stained tissue sections of surgical specimens. Patients with more than 50% intratumor stroma were quantified as the stroma-rich group and those with less than 50% as the stroma-poor group.
resultsIn 73 cases of tissue samples, 46 cases were included in the stroma-poor group, while 27 cases in stroma-rich group. The different expression of TSR in NSCLC tissue was not correlated with gender, age and pathological type, lymph node metastasis, tumor size, pTNM staging, and so on. Kaplan-Meier survival analysis showed that the different expression of TSR was significantly correlated with survival days (P=0.014). Cox regression analysis showed that not only different expression of TSR is a independent prognostic factor for NSCLC (HR=1.832, 95%CI: 1.017-3.299), but also pTNM staging (HR=1.953, 95%CI: 1.284-2.970).
conclusionsThe different expression of TSR might be an independent prognostic factor in NSCLC.
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