Trial reportRespiratory research2013
Impact of exacerbations of cystic fibrosis on muscle strength.
Trial report in Respiratory research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- The 2025 European Cystic Fibrosis Society position statement on physical activity assessment in cystic fibrosis.European respiratory review : an official journal of the European Respiratory Society · 2025Guideline
- Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: A systematic review and meta-analysis.Redox biology · 2020Pooled it
- How much do hospitalized adults move? A systematic review and meta-analysis.Applied nursing research : ANR · 2020Pooled it
- Change in skeletal muscle associated with unplanned hospital admissions in adult patients: A systematic review and meta-analysis.PloS one · 2019Pooled it
- Exercise capacity and muscle fatiguability alterations following a progressive maximal exercise of lower extremities in children with cystic fibrosis.African health sciences · 2018Trial
- Peripheral muscle oxygenation during upper extremity functional exercise and balance in pediatric patients with cystic fibrosis: a cross-sectional study.European journal of applied physiology · 2026Article
- Body Composition Changes in Hospitalized Patients with Community-Acquired Pneumonia.Journal of clinical medicine · 2025Article
- Guidance and standard operating procedures for functional exercise testing in cystic fibrosis.European respiratory review : an official journal of the European Respiratory Society · 2023Review
- Telemedicine and Its Application in Cystic Fibrosis.Journal of personalized medicine · 2023Review
- Physical Activity and Quality of Life among Patients with Cystic Fibrosis.Children (Basel, Switzerland) · 2022Article
- Impaired regenerative capacity contributes to skeletal muscle dysfunction in chronic obstructive pulmonary disease.American journal of physiology. Cell physiology · 2022Review
- Physical activity and its correlates in people with cystic fibrosis: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- One-minute sit-to-stand test is practical to assess and follow the muscle weakness in cystic fibrosis.Respiratory research · 2022Article
- New strategies of physical activity assessment in cystic fibrosis: a pilot study.BMC pulmonary medicine · 2020Article
- FACTORS ASSOCIATED TO QUALITY OF LIFE IN CHILDREN AND ADOLESCENTS WITH CYSTIC FIBROSIS.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2020Article
- Steps Ahead: optimising physical activity in adults with cystic fibrosis: Study Protocol for a pilot randomised trial using wearable technology, goal setting and text message feedback.HRB open research · 2020Article
- Nutritional status and muscle dysfunction in chronic respiratory diseases: stable phase versus acute exacerbations.Journal of thoracic disease · 2018Review
- Respiratory Muscle Strength and Exercise Performance in Cystic Fibrosis-A Cross Sectional Study.Frontiers in pediatrics · 2018Article
- CrossTalk opposing view: Skeletal muscle oxidative capacity is not altered in cystic fibrosis patients.The Journal of physiology · 2017Article
- Physiotherapy for cystic fibrosis in Australia and New Zealand: A clinical practice guideline.Respirology (Carlton, Vic.) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdult patients with cystic fibrosis have peripheral muscle weakness, which is related to exercise intolerance and poor prognosis. The influence of acute exacerbations on muscle strength has been poorly studied. This study aimed to investigate whether quadriceps force (QF), as assessed with an involuntary technique, changes during intravenous antibiotics therapy (IVAT) for an exacerbation.
methodsQF was measured in 20 patients using twitch stimulation of the femoral nerve at the day of hospitalization (day 1) and at termination (day 14) of the IVAT. Physical activity was monitored during IVAT using a SenseWear armband. Ten stable patients served as control subjects.
resultsQF did not change during exacerbation (potentiated twitch force at day 1: 140 ± 42 N, at day 14: 140 ± 47 N), but a decrease was observed in individual patients. Changes in twitch force during exacerbation were correlated with time spent in activities of at least moderate intensity (r = 0.61, p = 0.007).
conclusionsQF does not systematically decrease during exacerbations of cystic fibrosis. Individual changes in QF are well correlated with daily time spent in activities of at least moderate intensity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.