ArticleCancer science2013
Adult T-cell leukemia cells are characterized by abnormalities of Helios expression that promote T cell growth.
Article in Cancer science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Disease-associated AIOLOS variants lead to immune deficiency/dysregulation by haploinsufficiency and redefine AIOLOS functional domains.The Journal of clinical investigation · 2024Article
- IMiD/CELMoD-induced growth suppression of adult T-cell leukemia/lymphoma cellsFrontiers in oncology · 2023Article
- High Expression of IKZF2 in Malignant T Cells Promotes Disease Progression in Cutaneous T Cell Lymphoma.Acta dermato-venereologica · 2021Article
- The HTLV-1 viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape.PLoS pathogens · 2021Article
- Clinical application of genomic aberrations in adult T-cell leukemia/lymphoma.Journal of clinical and experimental hematopathology : JCEH · 2020Review
- Coexpression of FOXP3 and a Helios isoform enhances the effectiveness of human engineered regulatory T cells.Blood advances · 2020Article
- Molecular heterogeneity in peripheral T-cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling.Leukemia · 2019Article
- IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation.Cell stem cell · 2019Article
- A comprehensive manually-curated compendium of bovine transcription factors.Scientific reports · 2018Article
- An activating mutation of interferon regulatory factor 4 (IRF4) in adult T-cell leukemia.The Journal of biological chemistry · 2018Article
- Role of a non-canonical splice variant of theOncology letters · 2018Article
- Genetic alterations in adult T-cell leukemia/lymphoma.Cancer science · 2017Review
- Expression and splicing of Ikaros family members in murine and human thymocytes.Molecular immunology · 2017Article
- Expression of Helios in gastric tumor cells predicts better survival in gastric cancer patients.Journal of cancer research and clinical oncology · 2016Article
- Integrated molecular analysis of adult T cell leukemia/lymphoma.Nature genetics · 2015Article
- Interferon-γ Promotes Inflammation and Development of T-Cell Lymphoma in HTLV-1 bZIP Factor Transgenic Mice.PLoS pathogens · 2015Article
- Alternative splicing of DNA damage response genes and gastrointestinal cancers.World journal of gastroenterology · 2014Review
- Adult T-cell leukemia cells are characterized by abnormalities of Helios expression that promote T cell growth.Cancer science · 2013Article
- Alternative Splice Variants Modulates Dominant-Negative Function of Helios in T-Cell Leukemia.PloS oneArticle
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular abnormalities involved in the multistep leukemogenesis of adult T-cell leukemia (ATL) remain to be clarified. Based on our integrated database, we focused on the expression patterns and levels of Ikaros family genes, Ikaros, Helios, and Aiolos, in ATL patients and HTLV-1 carriers. The results revealed profound deregulation of Helios expression, a pivotal regulator in the control of T-cell differentiation and activation. The majority of ATL samples (32/37 cases) showed abnormal splicing of Helios expression, and four cases did not express Helios. In addition, novel genomic loss in Helios locus was observed in 17/168 cases. We identified four ATL-specific short Helios isoforms and revealed their dominant-negative function. Ectopic expression of ATL-type Helios isoform as well as knockdown of normal Helios or Ikaros promoted T-cell growth. Global mRNA profiling and pathway analysis showed activation of several signaling pathways important for lymphocyte proliferation and survival. These data provide new insights into the molecular involvement of Helios function in the leukemogenesis and phenotype of ATL cells, indicating that Helios deregulation is one of the novel molecular hallmarks of ATL.
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