ArticleHemoglobin2013
Leg ulcers in sickle cell disease: current patterns and practices.
Article in Hemoglobin, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Effect of Photobiomodulation in the Management of Leg Ulcers in Sickle Cell Disease: A Systematic Review.International wound journal · 2026Pooled it
- Interventions for treating leg ulcers in people with sickle cell disease.The Cochrane database of systematic reviews · 2021Pooled it
- Acupuncture as a Complementary Treatment for Leg Ulcers in Sickle-Cell Disease.Medical acupuncture · 2024Article
- Sickle cell leg ulcer successfully managed by hyperbaric oxygen: a case report.Frontiers in medicine · 2023Article
- Patient-Reported Experiences in Voxelotor-Treated Children and Adults with Sickle Cell Disease: A Semistructured Interview Study.BioMed research international · 2023Article
- Clinical and laboratory characterization of adult sickle cell anemia patients in Kinshasa.PloS one · 2022Article
- Prevalence of people with sickle cell disease and leg ulcers in Brazil: Socioeconomic and clinical overview.PloS one · 2022Article
- Insights into the skin microbiome of sickle cell disease leg ulcers.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2021Article
- The impact of voxelotor treatment on leg ulcers in patients with sickle cell disease.American journal of hematology · 2021Article
- Biosensors for Point Mutation Detection.Frontiers in bioengineering and biotechnology · 2021Article
- A study of the geographic distribution and associated risk factors of leg ulcers within an international cohort of sickle cell disease patients: the CASiRe group analysis.Annals of hematology · 2020Article
- American Society of Hematology 2020 guidelines for sickle cell disease: management of acute and chronic pain.Blood advances · 2020Article
- Whole-exome sequencing indicatesExperimental biology and medicine (Maywood, N.J.) · 2019Article
- Leg ulcer induced by hydroxycarbamide in sickle cell disease: What is the therapeutic impact?International wound journal · 2019Article
- Atypical Ulcers: Diagnosis and Management.Clinical interventions in aging · 2019Article
- Iron Chelation with Transdermal Deferoxamine Accelerates Healing of Murine Sickle Cell Ulcers.Advances in wound care · 2018Article
- Chronic complications and quality of life of patients living with sickle cell disease and receiving care in three hospitals in Cameroon: a cross-sectional study.BMC hematology · 2017Article
- A treatment algorithm to identify therapeutic approaches for leg ulcers in patients with sickle cell disease.International wound journal · 2016Review
- RX of sickle cell leg ulcers.International wound journal · 2016Article
- The Measure of Sickle Cell Stigma: Initial findings from the Improving Patient Outcomes through Respect and Trust study.Journal of health psychology · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Leg ulcers are a debilitating complication of patients with sickle cell disease, and their frequency in North America was reported to be 2.5% by the Cooperative Study of Sickle Cell Disease more than 20 years ago. We sought to determine if the frequency of leg ulcers in sickle cell patients in the United States had declined and to assess which treatments providers use most commonly. We sent an e-mail survey to health professionals belonging to the national Sickle Cell Adult Provider Network. Responses were obtained from 31 of them (26.0%). Most of them (96.0%) reported having some patients with leg ulcers. Providers reported a total of 185 patients with active leg ulcers and 224 in the previous 5 years, for a total of 409 patients. Hb SS (homozygous sickle cell anemia) was the most common genotype of affected individuals, followed by Hb SC (double heterozygote for Hb S [β6(A3)Glu→Val, GAG>GTG; HBB: c.20A>T] and Hb C [β6(A3)Glu→Lys, GAG>AAG; HBB: c.19G>A]). Males showed a 2:1 predominance. Two-thirds of patients were treated with either hydroxyurea (HU) or transfusion therapy and most used compression stockings and topical therapies as directed by wound care services. We conclude that leg ulcers continue to be a debilitating complication of young adults with sickle cell disease, despite improved supportive care and the widespread use of disease modifying agents such HU and transfusion. While some providers offer office-based ulcer care, the majority prefer specialty consultation including podiatry, plastic surgery and dermatology. Despite their frequency, there is no clear consensus among providers as to the best treatment.
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Registered trials
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