ArticleACS chemical neuroscience2013
Restricted diffusion of dopamine in the rat dorsal striatum.
Article in ACS chemical neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Toward Precise Modeling of Dopamine Release Kinetics: Comparison and Validation of Kinetic Models Using Voltammetry.ACS omega · 2024Article
- In vivo evidence for the unique kinetics of evoked dopamine release in the patch and matrix compartments of the striatum.Analytical and bioanalytical chemistry · 2021Article
- Regional Variation in Striatal Dopamine Spillover and Release Plasticity.ACS chemical neuroscience · 2020Article
- Direct in Vivo Electrochemical Detection of Resting Dopamine Using Poly(3,4-ethylenedioxythiophene)/Carbon Nanotube Functionalized Microelectrodes.Analytical chemistry · 2019Article
- Ex Vivo Measurement of Electrically Evoked Dopamine Release in Zebrafish Whole Brain.ACS chemical neuroscience · 2017Article
- Enhanced dopamine detection sensitivity by PEDOT/graphene oxide coating on in vivo carbon fiber electrodes.Biosensors & bioelectronics · 2017Article
- Computational Modeling of Neurotransmitter Release Evoked by Electrical Stimulation: Nonlinear Approaches to Predicting Stimulation-Evoked Dopamine Release.ACS chemical neuroscience · 2017Article
- Hypothalamic arcuate nucleus tyrosine hydroxylase neurons play orexigenic role in energy homeostasis.Nature neuroscience · 2016Article
- Enhanced Intracranial Microdialysis by Reduction of Traumatic Penetration Injury at the Probe Track.ACS chemical neuroscience · 2016Article
- Clearance of rapid adenosine release is regulated by nucleoside transporters and metabolism.Pharmacology research & perspectives · 2015Article
- A review of the effects of FSCV and microdialysis measurements on dopamine release in the surrounding tissue.The Analyst · 2015Review
- Kinetic diversity of dopamine transmission in the dorsal striatum.Journal of neurochemistry · 2015Article
- A novel restricted diffusion model of evoked dopamine.ACS chemical neuroscience · 2014Review
- Region- and domain-dependent action of nomifensine.The European journal of neuroscience · 2014Article
- The dopamine patchwork of the rat nucleus accumbens core.The European journal of neuroscience · 2013Article
- Heterogeneities in Axonal Structure and Transporter Distribution Lower Dopamine Reuptake Efficiency.eNeuroArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Recent evidence has shown that the dorsal striatum of the rat is arranged as a patchwork of domains that exhibit distinct dopamine kinetics and concentrations. This raises the pressing question of how these distinct domains are maintained, especially if dopamine is able to diffuse through the extracellular space. Diffusion between the domains would eliminate the concentration differences and, thereby, the domains themselves. The present study is a closer examination of dopamine's ability to diffuse in the extracellular space. We used voltammetry to record dopamine overflow in dorsal striatum while stimulating the medial forebrain bundle over a range of stimulus currents and frequencies. We also examined the effects of drugs that modulated the dopamine release (raclopride and quinpirole) and uptake (nomifensine). Examining the details of the temporal features of the evoked profiles reveals no clear evidence for long-distance diffusion of dopamine between fast and slow domains, even though uptake inhibition by nomifensine clearly prolongs the time that dopamine resides in the extracellular space. Our observations support the conclusion that striatal tissue has the capacity to retain dopamine molecules, thereby limiting its tendency to diffuse through the extracellular space.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.