Is it time to consider photobiomodulation as a drug equivalent?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. Does low level laser therapy has effects on inflammatory biomarkers IL-1β, IL-6, TNF-α, and MMP-13 in osteoarthritis of rat models-a systemic review and meta-analysis.Lasers in medical science · 2021
   Pooled it
2. LED photobiomodulation effect on the bleaching-induced sensitivity with hydrogen peroxide 35%-a controlled randomized clinical trial.Clinical oral investigations · 2022
   Trial
3. Photobiomodulation via a cluster device associated with a physical exercise program in the level of pain and muscle strength in middle-aged and older women with knee osteoarthritis: a randomized placebo-controlled trial.Lasers in medical science · 2020
   Trial
4. Light-emitting diode therapy (LEDT) before matches prevents increase in creatine kinase with a light dose response in volleyball players.Lasers in medical science · 2015
   Trial
5. Effect of Photobiomodulation on Proliferative Changes in the Retina: Evidence from an In Vitro Model of PVR.Advances in experimental medicine and biology · 2025
   Article
6. Examining the combined benefits of photobiomodulation and apigenin for the treatment of asthenozoospermia: An innovative therapeutic strategy.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024
   Article
7. Potential of combined red and near-infrared photobiomodulation to mitigate pro-osteoclastic and inflammatory gene expression in human mandibular osteogenic cells.Lasers in medical science · 2024
   Article
8. Comparing the effects of low-level laser therapy and gaseous ozone as a preventive measure on medication-related osteonecrosis of the jaws following tooth extraction: a rat model.European journal of medical research · 2024
   Article
9. Assessment of the pre-emptive effect of photobiomodulation in the postoperative period of impacted lower third molar extractions: A randomized, controlled, double-blind study protocol.PloS one · 2024
   Article
10. Photobiomodulation Therapy Improves Inflammatory Responses by Modifying Stereological Parameters, microRNA-21 and FGF2 Expression.Journal of lasers in medical sciences · 2023
    Article
11. Photobiomodulation at Defined Wavelengths Regulates Mitochondrial Membrane Potential and Redox Balance in Skin Fibroblasts.Oxidative medicine and cellular longevity · 2023
    Article
12. Photobiomodulation and nitric oxide signaling.Nitric oxide : biology and chemistry · 2023
    Review
13. Dual near-infrared II laser modulates the cellular redox state of T cells and augments the efficacy of cancer immunotherapy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
14. Near-infrared II photobiomodulation augments nitric oxide bioavailability via phosphorylation of endothelial nitric oxide synthase.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
15. Quickly evolving near-infrared photoimmunotherapy provides multifaceted approach to modern cancer treatment.View (Beijing, China) · 2022
    Article
16. Fluorescent Light Energy and Chronic Lesions: A Winning Association.Plastic and reconstructive surgery. Global open · 2021
    Article
17. Effects of photobiomodulation on the redox state of healthy and cancer cells.Biomedical optics express · 2021
    Article
18. Photobiomodulation of Human Fibroblasts and Keratinocytes with Blue Light: Implications in Wound Healing.Biomedicines · 2021
    Article
19. Photobiomodulation Dose Parameters in Dentistry: A Systematic Review and Meta-Analysis.Dentistry journal · 2020
    Review
20. Marine collagen scaffolds and photobiomodulation on bone healing process in a model of calvaria defects.Journal of bone and mineral metabolism · 2020
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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