ArticleOman medical journal2013
Prevalence of Extended-spectrum β-Lactamases-producing Escherichia coli from Hospitals in Khartoum State, Sudan.
Article in Oman medical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Antimicrobial resistance in Africa: a systematic review.BMC infectious diseases · 2017Pooled it
- Antimicrobial resistance, biofilm formation, and molecular detection of efflux pump and biofilm genes amongHeliyon · 2024Article
- Extended-spectrum β-lactamase and carbapenemase producingFrontiers in microbiology · 2024Article
- Molecular Epidemiology of Antibiotic Resistance Genes and Virulence Factors in Multidrug-ResistantInternational journal of environmental research and public health · 2022Article
- Multi-Drug Resistance Profile, Prevalence of Extended-Spectrum Beta-Lactamase and Carbapenemase-Producing Gram Negative Bacilli Among Admitted Patients After Surgery with Suspected of Surgical Site Nosocomial Infection North East Ethiopia.Infection and drug resistance · 2022Article
- Retrospective Analysis on Antimicrobial Resistance Trends and Prevalence of β-lactamases inMicroorganisms · 2020Review
- Article
- Bacteriospermia, extended spectrum beta lactamase producing Gram-negative bacteria and other factors associated with male infertility in Mwanza, Tanzania: a need of diagnostic bacteriology for management of male infertility.African health sciences · 2020Article
- Prevalence of extended-spectrum β-lactamase (ESBL) and molecular detection ofThe Pan African medical journal · 2020Article
- Pathogenic spectrum of blood stream infections and resistance pattern in Gram-negative bacteria from Aljouf region of Saudi Arabia.PloS one · 2020Article
- Antimicrobial Resistance, Virulence Factors, and Pathotypes ofPathogens (Basel, Switzerland) · 2019Article
- Phenotypic Characterization and Antibiotic Resistance Patterns of Extended-SpectrumThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2019Article
- Phenotypic prevalence of extended spectrum beta-lactamases among enterobacteriaceae isolated at Mulago National Referral Hospital: Uganda.BMC research notes · 2017Article
- Article
- Genetic diversity study of various β-lactamase-producing multidrug-resistantThe Indian journal of medical research · 2017Article
- Frequency of Extended-Spectrum Beta-lactamases (ESBLs) in strains of Klebsiella andElectronic physician · 2017Article
- Incidence and Etiology of Surgical Site Infections in Appendectomies: A 3-Year Prospective Study.Oman medical journal · 2017Article
- Prevalence of Extended-Spectrum Beta-Lactamases-Producing Microorganisms in Patients Admitted at KRRH, Southwestern Uganda.International journal of microbiology · 2017Article
- Antimicrobial susceptibility and molecular epidemiology of extended-spectrum beta-lactamase-producing Enterobacteriaceae from intensive care units at Hamad Medical Corporation, Qatar.Antimicrobial resistance and infection control · 2016Article
- Uropathogens and their antimicrobial resistance patterns: Relationship with urinary tract infections.International journal of health sciencesArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to determine the prevalence and assess antimicrobial susceptibility of extended- spectrum β-lactamase-producing Escherichia coli isolated from clinical specimens of patients at hospitals in Khartoum State, Sudan.
methodsDuring April to August 2011, a total of 232 E. coli isolates were collected from various clinical specimens of patients. Isolates were identified, tested for antimicrobial susceptibility and screened for ESBL production as per standard methods. The double-disk diffusion method was used to confirm ESBL production using antimicrobial disks of ceftazidime (30 μg), cefotaxime (30 μg), with or without clavulanic acid (10 μg). A zone difference of >5 mm between disks was considered indicative of ESBL production.
resultsOut of 232 E. coli isolates, 70 (30.2%) were found to be positive for ESBL by the applied phenotypic methods. ESBL-producing isolates yielded high resistance rates for trimethoprim-sulfamethoxazole (98.6%), tetracycline (88.6%), nalidixic acid (81.4%) and ciprofloxacin (81.4%). The highest antimicrobial activities of ESBL-producing isolates were observed for amikacin (95.7%), followed by tobramicin (74.3%) and nitrofurantoin (68.6%). Resistance to quinolones, aminoglycosides, trimethoprim-sulfamethoxazole, tetracycline, nitrofurantoin and chloramphenicol was higher in ESBL than non-ESBL isolates (p<0.05). The frequency of ESBL-producing isolates varied among hospitals (18.2% to 45.1%), although a high prevalence was recorded as 45.1% at Khartoum Teaching Hospital. Wound specimens were the most common source of ESBL-producing isolates. The proportion of ESBL-producing E. coli did not differ significantly between adults and children (31% vs. 27%).
conclusionThe prevalence of ESBL-producing E. coli detected in this study is of great concern, which requires sound infection control measures including antimicrobial management and detection of ESBL-producing isolates.
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