ArticleHepatitis monthly2013
Correlation between viral load of HBV in chronic hepatitis B patients and precore and Basal core promoter mutations.
Article in Hepatitis monthly, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Real-world experience with nucleos(t)ide analogue therapy and patient survival rates in chronic viral hepatitis B treatment centers in Eritrea.Scientific reports · 2025Article
- Hepatitis B in Pediatric Population: Observational Retrospective Study in Romania.Life (Basel, Switzerland) · 2024Article
- Association between host TNF-α, TGF-β1, p53 polymorphisms, HBV X gene mutation, HBV viral load and the progression of HBV-associated chronic liver disease in Indonesian patients.Biomedical reports · 2019Article
- Nucleotide Substitutions in Hepatitis B Viruses Derived from Chronic HBV Patients.Mediterranean journal of hematology and infectious diseases · 2019Article
- Serological and molecular characterization of hepatitis B virus in asymptomatic blood donors in Iran.Iranian journal of microbiology · 2018Article
- Characterization of the "a" determinant region of the hepatitis B virus genome in Iranian patients at different clinical phases of chronic infection.Gastroenterology and hepatology from bed to bench · 2018Article
- Genetic diversity, viraemic and aminotransferases levels in chronic infected hepatitis B patients from Cameroon.BMC research notes · 2016Article
- Molecular Characterization of Pre-Core/Core and S Region of Hepatitis B Virus in Hemodialysis Patients With Occult Hepatitis B Infection.Jundishapur journal of microbiology · 2015Article
- High rate of core promoter and precore mutations in patients with chronic hepatitis B.Hepatology international · 2015Article
- Variations and mutations in the hepatitis B virus genome and their associations with clinical characteristics.World journal of hepatology · 2015Review
- Mutations of Basal core promoter and precore regions in hepatitis B virus genotypes B and C.Hepatitis monthly · 2015Article
- Hepatitis B virus core promoter mutations in patients with chronic hepatitis B and hepatocellular carcinoma in bucharest, romania.Hepatitis monthly · 2014Article
- Hepatitis B virus genetic mutations and evolution in liver diseases.World journal of gastroenterology · 2014Review
- Core promoter: a critical region where the hepatitis B virus makes decisions.World journal of gastroenterology · 2014Review
- Effect of Hepatitis B Virus X Gene on the Expression Level of p53 Gene using Hep G2 Cell Line.Avicenna journal of medical biotechnology · 2014Article
- Hepatitis B virus precore/core region mutations and genotypes among hepatitis B virus chronic carriers in South-Eastern, Nigeria.International journal of health sciencesArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMore than two billion people have been exposed to hepatitis B virus (HBV) worldwide. Furthermore, four hundred million of them are infected with chronic HBV infection. The predominant mutation of the precore region involves a G to A change at nucleotide1896, which creates a premature stop codon at codon 28. Two mutations of A1762T and G1764A are reported as the most prevalent mutations in the basal core promoter (BCP).
objectivesThe purpose of this study was to investigate the relationship between mutations in precore (PC) and basal core promoter regions, and the viral load. PATIENTS AND
methodsFifty serum samples from patients with hepatitis B were used. Levels of liver enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured at the same time of serological markers of hepatitis B by ELISA. HBV-DNA was extracted from the sera, and then PCR performed on the HBV-DNA extracted with the use of specific primer of gene C. HBV viral load was determined by real-time PCR. The PC/ BCP mutations were determined by applying Line Probe Assay technique. The data were analyzed using SPSS software, version 20.
resultsOnly 82% of the patients were HBeAb positive and 76% of the patients had basal core/ precore mutations and mean viral load was 3/7 × 106 ± 9/7 × 105 IU/ml. Prevalence of mutations in the precore and basal core promoter regions were 46% and 30%, respectively.
conclusionsOur data indicated that there is a statistically significant relationship between HBV viral load and mutations in precore region (P < 0.05).
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