ArticleThe Journal of infectious diseases2013
Virulence of endemic nonpigmented northern Australian Staphylococcus aureus clone (clonal complex 75, S. argenteus) is not augmented by staphyloxanthin.
Article in The Journal of infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 60 citations in OpenAlex.
- Five-decade global expansion of Staphylococcus argenteus ST2250 shapes antimicrobial resistance dynamics.npj antimicrobials and resistance · 2026Article
- Analysis of Teg41 and PSMα promoter activity using a divergent fluorescent reporter plasmid.mSphere · 2025Article
- TheJournal of clinical microbiology · 2025Review
- Synthetic indole derivatives as an antibacterial agent inhibiting respiratory metabolism of multidrug-resistant gram-positive bacteria.Communications biology · 2024Article
- Virulence attributes of successful methicillin-resistantClinical microbiology reviews · 2023Review
- Black and White Patients With Staphylococcus aureus Bacteremia Have Similar Outcomes but Different Risk Factors.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Staphyloxanthin as a Potential Novel Target for Deciphering Promising Anti-Antibiotics (Basel, Switzerland) · 2022Review
- The First Case Report of Community-Acquired Infective Endocarditis Due to Sequence Type 1223Infection and drug resistance · 2022Article
- Phenotypic and Genomic Profiling of Staphylococcus argenteus in Canada and the United States and Recommendations for Clinical Result Reporting.Journal of clinical microbiology · 2021Article
- Complete Genome Sequences of Staphylococcus argenteus Tokyo13064 and Tokyo13069, Isolated from Specimens Obtained during a Food Poisoning Outbreak in Tokyo, Japan.Microbiology resource announcements · 2021Article
- Distribution of Virulence Factors and Resistance Determinants in Three Genotypes ofPathogens (Basel, Switzerland) · 2021Article
- Colonization withMicrobial genomics · 2021Article
- Evolutionary Divergence of the Novel Staphylococcal SpeciesFrontiers in microbiology · 2021Article
- Human infections caused by Staphylococcus argenteus in Germany: genetic characterisation and clinical implications of novel species designation.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
- Case Commentary: Daptomycin Resistance in Staphylococcus argenteus-from Northern Australia to San Francisco.Antimicrobial agents and chemotherapy · 2020Article
- Article
- The Whole-Genome Sequence of Plasmid-Bearing Staphylococcus argenteus Strain B3-25B from Retail Beef Liver Encodes the Type VII Secretion System and Several Virulence Factors.Microbiology resource announcements · 2019Article
- Staphylococci: Evolving Genomes.Microbiology spectrum · 2019Review
- Community-Acquired Staphylococcus argenteus Sequence Type 2250 Bone and Joint Infection, France, 2017.Emerging infectious diseases · 2018Article
- Which methods are appropriate for the detection ofInfection and drug resistance · 2018Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
Abstract
Staphylococcus aureus clonal complex 75 (herein referred to as S. argenteus) lacks the carotenoid pigment operon, crtOPQMN, responsible for production of the putative virulence factor, staphyloxanthin. Although a common cause of community-onset skin infections among Indigenous populations in northern Australia, this clone is infrequently isolated from hospital-based patients with either bacteremic or nonbacteremic infections. We hypothesized that S. argenteus would have attenuated virulence compared to other S. aureus strains due to its staphyloxanthin "deficiency." Compared to prototypical S. aureus strains, S. argenteus was more susceptible to oxidative stress and neutrophil killing in vitro and had reduced virulence in murine sepsis and skin infection models. Transformation with pTX-crtOPQMN resulted in staphyloxanthin expression and increased resistance to oxidative stress in vitro. However, neither resistance to neutrophil killing nor in vivo virulence was increased. Thus, reduced virulence of S. argenteus in these models is due to mechanisms unrelated to lack of staphyloxanthin production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.