ArticleSchizophrenia bulletin2014
Smooth pursuit eye movement, prepulse inhibition, and auditory paired stimuli processing endophenotypes across the schizophrenia-bipolar disorder psychosis dimension.
Article in Schizophrenia bulletin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prepulse inhibition deficit as a transdiagnostic process in neuropsychiatric disorders: a systematic review.BMC psychology · 2023Pooled it
- Meta-Analysis of Sensorimotor Gating Deficits in Patients With Schizophrenia Evaluated by Prepulse Inhibition Test.Schizophrenia bulletin · 2020Pooled it
- Prepulse inhibition in patients with bipolar disorder: a systematic review and meta-analysis.BMC psychiatry · 2019Pooled it
- Modafinil effects on middle-frequency oscillatory power during rule selection in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- Associations between smooth pursuit, predictive pursuit, anomalous self-experiences, and psychotic-like experiences.European archives of psychiatry and clinical neuroscience · 2026Article
- Brain Age Disparities in Psychosis Across DSM Diagnoses and B-SNIP Biotypes.Schizophrenia bulletin · 2026Article
- Startle response and its prepulse modification in health and under different psychopathologies: Could we find any specific patterns?World journal of psychiatry · 2025Review
- Abnormalities in cognitive-related functional connectivity can be used to identify patients with schizophrenia and individuals in clinical high-risk.BMC psychiatry · 2025Article
- Oculomotor Abnormalities and Aberrant Neuro-Developmental Markers: Composite Endophenotype for Bipolar I Disorder: Anomalies Oculomotrices et Marqueurs Neuro-Développementaux Aberrants : Endophénotype Composite du Trouble Bipolaire I.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2024Article
- Reduced amplitude and slowed latency of the acoustic startle response in adolescents and adults with 22q11.2 deletion syndrome.Schizophrenia research · 2024Article
- Evidence from comprehensive independent validation studies for smooth pursuit dysfunction as a sensorimotor biomarker for psychosis.Scientific reports · 2024Article
- Eye Movement Abnormalities Can Distinguish First-Episode Schizophrenia, Chronic Schizophrenia, and Prodromal Patients From Healthy Controls.Schizophrenia bulletin open · 2023Article
- Cognitive Impairment and Diminished Neural Responses Constitute a Biomarker Signature of Negative Symptoms in Psychosis.Schizophrenia bulletin · 2020Article
- Relationship of prolonged acoustic startle latency to diagnosis and biotype in the bipolar-schizophrenia network on intermediate phenotypes (B-SNIP) cohort.Schizophrenia research · 2020Article
- Disrupted Corollary Discharge in Schizophrenia: Evidence From the Oculomotor System.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Review
- Application of eye trackers for understanding mental disorders: Cases for schizophrenia and autism spectrum disorder.Neuropsychopharmacology reports · 2019Review
- Schizotypy and smooth pursuit eye movements as potential endophenotypes of obsessive-compulsive disorder.European archives of psychiatry and clinical neuroscience · 2019Article
- Correlations between exploratory eye movement, hallucination, and cortical gray matter volume in people with schizophrenia.BMC psychiatry · 2018Article
- Genome-wide association studies of smooth pursuit and antisaccade eye movements in psychotic disorders: findings from the B-SNIP study.Translational psychiatry · 2017Article
- Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia.Cell stem cell · 2017Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundThis study examined smooth pursuit eye movement (SPEM), prepulse inhibition (PPI), and auditory event-related potentials (ERP) to paired stimuli as putative endophenotypes of psychosis across the schizophrenia-bipolar disorder dimension.
methodsSixty-four schizophrenia probands (SZP), 40 psychotic bipolar I disorder probands (BDP), 31 relatives of SZP (SZR), 26 relatives of BDP (BDR), and 53 healthy controls (HC) were tested. Standard clinical characterization, SPEM, PPI, and ERP measures were administered.
resultsThere were no differences between either SZP and BDP or SZR and BDR on any of the SPEM, PPI, or ERP measure. Compared with HC, SZP and BDP had lower SPEM maintenance and predictive pursuit gain and ERP theta/alpha and beta magnitudes to the initial stimulus. PPI did not differ between the psychosis probands and HC. Compared with HC, SZR and BDR had lower predictive pursuit gain and ERP theta/alpha and beta magnitudes to the first stimulus with differences ranging from a significant to a trend level. Neither active symptoms severity nor concomitant medications were associated with neurophysiological outcomes. SPEM, PPI, and ERP scores had low intercorrelations.
conclusionThese findings support SPEM predictive pursuit and lower frequency auditory ERP activity in a paired stimuli paradigm as putative endophenotypes of psychosis common to SZ and BD probands and relatives. PPI did not differ between the psychosis probands and HC. Future studies in larger scale psychosis family samples targeting putative psychosis endophenotypes and underlying molecular and genetic mediators may aid in the development of biology-based diagnostic definitions.
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