Trial reportJAMA otolaryngology-- head & neck surgery2013
Low-frequency repetitive transcranial magnetic stimulation to the temporoparietal junction for tinnitus: four-week stimulation trial.
Trial report in JAMA otolaryngology-- head & neck surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00567892 (Collaborative Tinnitus Research at Washington University), which is not on this map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Collaborative Tinnitus Research at Washington University
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Repetitive transcranial magnetic stimulation on chronic tinnitus: a systematic review and meta-analysis.BMC psychiatry · 2020Pooled it
- RTMS parameters in tinnitus trials: a systematic review.Scientific reports · 2019Pooled it
- A multidisciplinary systematic review of the treatment for chronic idiopathic tinnitus.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Pooled it
- Perceptual and Cognitive Effects of Focal Transcranial Direct Current Stimulation of Auditory Cortex in Tinnitus.Neuromodulation : journal of the International Neuromodulation Society · 2025Trial
- The effect of noninvasive brain stimulation on neural connectivity in Tinnitus: A randomized trial.The Laryngoscope · 2016Trial
- Combined rTMS treatment targeting the Anterior Cingulate and the Temporal Cortex for the Treatment of Chronic Tinnitus.Scientific reports · 2015Trial
- Transdermal lidocaine as treatment for chronic subjective tinnitus: A pilot study.American journal of otolaryngologyTrial
- Neuronavigated Versus Non-navigated Repetitive Transcranial Magnetic Stimulation for Chronic Tinnitus: A Randomized Study.Trends in hearingTrial
- Digital twin brain reveals state-specific stimulation targets for abnormal brain dynamics in tinnitus.BMC medicine · 2026Article
- Case Report: Repeated courses of low-frequency rTMS for refractory tinnitus: an N-of-1 study.Frontiers in psychiatry · 2026Article
- Unresolved Issues Associated with Transcranial Magnetic Stimulation (TMS) Treatment of Chronic Tinnitus.Journal of clinical medicine · 2023Review
- Repetitive Transcranial Magnetic Stimulation for Tinnitus Treatment in Vestibular Schwannoma: A Pilot Study.Frontiers in neurology · 2021Article
- Association of Central Noninvasive Brain Stimulation Interventions With Efficacy and Safety in Tinnitus Management: A Meta-analysis.JAMA otolaryngology-- head & neck surgery · 2020Article
- Neural metabolic activity in idiopathic tinnitus patients after repetitive transcranial magnetic stimulation.World journal of clinical cases · 2019Article
- Repetitive transcranial magnetic stimulation and drugs for tinnitus.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Article
- Individualized Repetitive Transcranial Magnetic Stimulation Treatment in Chronic Tinnitus?Frontiers in neurology · 2017Article
- An Investigation of Feasibility and Safety of Bi-Modal Stimulation for the Treatment of Tinnitus: An Open-Label Pilot Study.Neuromodulation : journal of the International Neuromodulation Society · 2016Article
- Factor Analysis of Low-Frequency Repetitive Transcranial Magnetic Stimulation to the Temporoparietal Junction for Tinnitus.Neural plasticity · 2016Article
- Evidence and evidence gaps in tinnitus therapy.GMS current topics in otorhinolaryngology, head and neck surgery · 2016Review
- Repetitive transcranial magnetic stimulation improves both hearing function and tinnitus perception in sudden sensorineural hearing loss patients.Scientific reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
importanceThis research examines the impact of 4 weeks of repetitive transcranial magnetic stimulation (rTMS) stimulation to the temporoparietal junction and compares the results of this longer duration of treatment with a similar stimulus protocol of only 2 weeks' duration.
objectiveTo examine the effectiveness and safety of 4 weeks of low-frequency rTMS to the left temporoparietal junction in a cohort of patients with bothersome tinnitus.
designCrossover, double-blind, randomized controlled trial.
settingOutpatient academic medical center.
participantsThe study population comprised 14 adults aged between 22 and 59 years with subjective, unilateral or bilateral, nonpulsatile tinnitus of 6 months' duration or greater and a score of 34 or greater on the Tinnitus Handicap Inventory (THI).
interventionsLow-frequency (1 Hz) 110% motor threshold rTMS or sham to the left temporoparietal junction for 4 weeks. MAIN OUTCOME AND MEASURE: The difference of the change in the THI score between active rTMS and sham rTMS.
resultsActive treatment was associated with a median reduction in THI score of 10 (range, -20 to +4) points, and sham treatment was associated with a median reduction of 6 (range, -24 to +12) points. The median difference in THI score between the change associated with active and sham rTMS was 4 (95% CI, -9 to 10; and range, -32 to +14) points. CONCLUSIONS AND RELEVANCE: Daily low-frequency active rTMS to the left temporoparietal junction area for 4 weeks was no more effective than sham for patients with chronic bothersome tinnitus. Possible explanations for this negative study include the failure of rTMS to stimulate deeper parts of auditory cortex within the sylvian fissure and more widespread cortical network changes not amenable to localized rTMS effects.
trial registrationclinicaltrials.gov Identifier: NCT00567892.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.