Trial reportThe American journal of psychiatry2013
D-Cycloserine as an augmentation strategy with cognitive-behavioral therapy for social anxiety disorder.
Trial report in The American journal of psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03216356 (Effect of D-cycloserine on a Short Imagery Rescripting Intervention for Subclinical PTSD), which is not on this map. Cited by 50 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of D-cycloserine on a Short Imagery Rescripting Intervention for Subclinical PTSD
Who cites it
50 citing papers in PubMed, 4 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- A Meta-Analysis of D-Cycloserine in Exposure-Based Treatment: Moderators of Treatment Efficacy, Response, and Diagnostic Remission.The Journal of clinical psychiatry · 2017Pooled it
- D-cycloserine augmentation of behavior therapy for anxiety and obsessive-compulsive disorders: A meta-analysis.PloS one · 2017Pooled it
- D-Cycloserine in Neuropsychiatric Diseases: A Systematic Review.The international journal of neuropsychopharmacology · 2016Pooled it
- Augmentation of cognitive and behavioural therapies (CBT) with d-cycloserine for anxiety and related disorders.The Cochrane database of systematic reviews · 2015Pooled it
- Trial
- Dose Timing of D-Cycloserine to Augment Exposure Therapy for Social Anxiety Disorder: A Randomized Clinical Trial.JAMA network open · 2020Trial
- Enhancing panic and smoking reduction treatment with D-Cycloserine: A pilot randomized clinical trial.Drug and alcohol dependence · 2020Trial
- Effect of d-cycloserine on fear extinction training in adults with social anxiety disorder.PloS one · 2019Trial
- D-Cycloserine augmentation of cognitive behavior therapy for pediatric OCD: Predictors and moderators of outcome.Journal of affective disorders · 2018Trial
- Early effects of exposure-based cognitive behaviour therapy on the neural correlates of anxiety.Translational psychiatry · 2018Trial
- RANDOMIZED TRIAL OF D-CYCLOSERINE ENHANCEMENT OF COGNITIVE-BEHAVIORAL THERAPY FOR PANIC DISORDER.Depression and anxiety · 2016Trial
- Efficacy of Augmentation of Cognitive Behavior Therapy With Weight-Adjusted d-Cycloserine vs Placebo in Pediatric Obsessive-Compulsive Disorder: A Randomized Clinical Trial.JAMA psychiatry · 2016Trial
- Baseline psychophysiological and cortisol reactivity as a predictor of PTSD treatment outcome in virtual reality exposure therapy.Behaviour research and therapy · 2016Trial
- The desire to belong: Social identification as a predictor of treatment outcome in social anxiety disorder.Behaviour research and therapy · 2016Trial
- Evaluating changes in judgmental biases as mechanisms of cognitive-behavioral therapy for social anxiety disorder.Behaviour research and therapy · 2015Trial
- Dose timing of D-cycloserine to augment cognitive behavioral therapy for social anxiety: Study design and rationale.Contemporary clinical trials · 2015Trial
- D-Cycloserine facilitation of exposure therapy improves weight regain in patients with anorexia nervosa: a pilot randomized controlled trial.The Journal of clinical psychiatry · 2015Trial
- Exercise Augmentation of Exposure Therapy for PTSD: Rationale and Pilot Efficacy Data.Cognitive behaviour therapy · 2015Trial
- Effects of post-session administration of methylene blue on fear extinction and contextual memory in adults with claustrophobia.The American journal of psychiatry · 2014Trial
- A randomized, double-blind evaluation of D-cycloserine or alprazolam combined with virtual reality exposure therapy for posttraumatic stress disorder in Iraq and Afghanistan War veterans.The American journal of psychiatry · 2014Trial
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe authors examined whether D-cycloserine, a partial agonist at the glutamatergic N-methyl-d-aspartate receptor, augments and accelerates a full course of comprehensive cognitive-behavioral therapy (CBT) in adults with generalized social anxiety disorder.
methodThis was a multisite randomized placebo-controlled efficacy study with 169 medication-free adults with generalized social anxiety disorder, of whom 144 completed the 12-week treatment and 131 completed the three follow-up assessments. Patients were randomly assigned to receive 50 mg of D-cycloserine or placebo 1 hour before each of five exposure sessions that were part of a 12-session cognitive-behavioral group treatment. Response and remission status was determined at baseline, throughout treatment, at end of treatment, and at 1-, 3-, and 6-month follow-up assessments by assessors who were blind to treatment condition.
resultsD-Cycloserine-augmented and placebo-augmented CBT were associated with similar completion rates (87% and 82%), response rates (79.3% and 73.3%), and remission rates (34.5% and 24.4%) at the posttreatment assessment; response and remission rates were largely maintained at the follow-up assessments. Although D-cycloserine was associated with a 24%-33% faster rate of improvement in symptom severity and remission rates relative to placebo during the treatment phase, the groups did not differ in response and remission rates.
conclusionsD-Cycloserine did not augment a full course of comprehensive CBT for social anxiety disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.