ReviewMinerva ginecologica2013
Medical management of endometriosis: emerging evidence linking inflammation to disease pathophysiology.
Review in Minerva ginecologica, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 60 citations in OpenAlex.
- Effect of simvastatin on monocyte chemoattractant protein-1 expression in endometriosis patients: a randomized controlled trial.BMC women's health · 2017Trial
- Exploring the therapeutic potential of H1-antihistamines in endometriosis-A gene regulation-based perspective.Frontiers in medicine · 2025Article
- The role of progesterone and estrogen receptors in treatment choice after endometriosis surgery: A cross-sectional study.International journal of reproductive biomedicine · 2024Article
- The Impacts of Inflammatory and Autoimmune Conditions on the Endometrium and Reproductive Outcomes.Journal of clinical medicine · 2024Review
- Association of endometriosis with asthma: a study of the NHANES database in 1999-2006.Journal of health, population, and nutrition · 2024Article
- Effects of the gut microbiota and its metabolite short-chain fatty acids on endometriosis.Frontiers in cellular and infection microbiology · 2024Review
- An opinion on H1-antihistamines as a potential avenue for endometriosis management.AJOG global reports · 2023Article
- Evaluation of Soluble CD90: Potential for Diagnostic Significance in Endometriosis Patients.Disease markers · 2022Article
- The gut microbiota and endometriosis: From pathogenesis to diagnosis and treatment.Frontiers in cellular and infection microbiology · 2022Review
- Administration of red ginseng regulates microRNA expression in a mouse model of endometriosis.Clinical and experimental reproductive medicine · 2021Article
- Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu.Communications biology · 2021Article
- Macrophage depletion: a potential immunomodulator treatment of endometriosis-associated pain?Annals of translational medicine · 2020Article
- Bioinformatic analysis reveals the importance of epithelial-mesenchymal transition in the development of endometriosis.Scientific reports · 2020Article
- Environmental Endocrine Disruptors and Endometriosis.Advances in anatomy, embryology, and cell biology · 2020Review
- Dose-Dependent Decreased Fertility in Response to the Burden of Endometriosis in a Murine Model.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- The endometrial immune environment of women with endometriosis.Human reproduction update · 2019Review
- Progesterone Receptor Status Predicts Response to Progestin Therapy in Endometriosis.The Journal of clinical endocrinology and metabolism · 2018Article
- Unfolded protein response, a link between endometrioid ovarian carcinoma and endometriosis: A pilot study.Oncology letters · 2018Article
- Absence of formyl peptide receptor 1 causes endometriotic lesion regression in a mouse model of surgically-induced endometriosis.Oncotarget · 2018Article
- Analysis of CARD10 and CARD11 somatic mutations in patients with ovarian endometriosis.Oncology letters · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Progesterone action normally mediates the balance between anti-inflammatory and proinflammatory processes throughout the female reproductive tract. However, in women with endometriosis, endometrial progesterone resistance, characterized by alterations in progesterone responsive gene and protein expression, is now considered a central element in disease pathophysiology. Recent studies additionally suggest that the peritoneal microenvironment of endometriosis patients exhibits altered physiological characteristics that may further promote inflammation-driven disease development and progression. Within this review, we summarize our current understanding of the pathogenesis of endometriosis with an emphasis on the role that inflammation plays in generating not only the progesterone-resistant eutopic endometrium but also a peritoneal microenvironment that may contribute significantly to disease establishment. Viewing endometriosis from the emerging perspective that a progesterone resistant endometrium and an immunologically compromised peritoneal microenvironment are biologically linked risk factors for disease development provides a novel mechanistic framework to identify new therapeutic targets for appropriate medical management.
Indexed as
Identifiers
23598784PMC3718308W1520611110What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.