ArticleAge (Dordrecht, Netherlands)2005
Stem cell aging in the Drosophila ovary.
Article in Age (Dordrecht, Netherlands), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Review
- Article
- Rapid Functional and Sequence Differentiation of a Tandemly Repeated Species-Specific Multigene Family in Drosophila.Molecular biology and evolution · 2017Article
- Used protocols for isolation and propagation of ovarian stem cells, different cells with different traits.Journal of ovarian research · 2016Review
- Review
- An evolutionary perspective on adult female germline stem cell function from flies to humans.Seminars in reproductive medicine · 2013Review
- The next (re)generation of ovarian biology and fertility in women: is current science tomorrow's practice?Fertility and sterility · 2012Review
- Parental age and lifespan influence offspring recruitment: a long-term study in a seabird.PloS one · 2011Article
- Bcl-2 proteins and autophagy regulate mitochondrial dynamics during programmed cell death in the Drosophila ovary.Development (Cambridge, England) · 2011Article
- Conditional inactivation of MRG15 gene function limits survival during larval and adult stages of Drosophila melanogaster.Experimental gerontology · 2010Article
- Reproductive aging in invertebrate genetic models.Annals of the New York Academy of Sciences · 2010Article
- Adult-specific over-expression of the Drosophila genes magu and hebe increases life span and modulates late-age female fecundity.Molecular genetics and genomics : MGG · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence suggests that with time human stem cells may become defective or depleted, thereby contributing to aging and aging-related diseases. Drosophila provides a convenient model system in which to study stem cell aging. The adult Drosophila ovary contains two types of stem cells: the germ-line stem cells give rise to the oocyte and its supporting nurse cells, while the somatic stem cells give rise to the follicular epithelium-a highly differentiated tissue that surrounds each oocyte as it develops. Genetic and transgenic analyses have identified several conserved signaling pathways that function in the ovary to regulate stem cell maintenance, division and differentiation, including the wingless, hedgehog, JAK/STAT, insulin and TGF-β pathways. During Drosophila aging the division of the stem cells decreases dramatically, coincident with reduced egg production. It is unknown if this reproductive senescence is due to a defect in the stem cells themselves, or due to the lack of signals normally sent to the stem cells from elsewhere in the animal, such as from the central nervous system or the stem cell niche. Methods are being developed to genetically mark stem cells in adult Drosophila and measure their survival, division rate and function during aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.