ArticleAge (Dordrecht, Netherlands)2005
Phenotype screening for genetically determined age-onset disorders and increased longevity in ENU-mutagenized mice.
Article in Age (Dordrecht, Netherlands), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- The short-lived African turquoise killifish: an emerging experimental model for ageing.Disease models & mechanisms · 2016Review
- New insights into behaviour using mouse ENU mutagenesis.Human molecular genetics · 2012Review
- Evaluation of animal models of neurobehavioral disorders.Behavioral and brain functions : BBF · 2009Article
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Authors and funding
12 authors at 4 institutions in 1 country.
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Abstract
With the goal of discovering genes that contribute to late-onset neurological and ocular disorders and also genes that extend the healthy life span in mammals, we are phenotyping mice carrying new mutations induced by the chemical N-ethyl-N-nitrosourea (ENU). The phenotyping plan includes basic behavioral, neurohistological, and vision testing in sibling cohorts of mice aged to 18 months, and then evaluation for markers of growth trajectory and stress response in these same cohorts aged up to 28 months. Statistical outliers are identified by comparison to test results of similar aged cohorts, and potential mutants are recovered for re-aging to confirm heritability of the phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.