ArticleRNA (New York, N.Y.)2013
Analysis and design of RNA sequencing experiments for identifying RNA editing and other single-nucleotide variants.
Article in RNA (New York, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- RNA editing in cardiovascular health and disease.Communications biology · 2026Review
- Genetic architecture of RNA editing, splicing and gene expression in schizophrenia.Human molecular genetics · 2025Article
- Navigating the landscape of epitranscriptomics and host immunity.Genome research · 2024Review
- Recommendations for detection, validation, and evaluation of RNA editing events in cardiovascular and neurological/neurodegenerative diseases.Molecular therapy. Nucleic acids · 2024Review
- Genetic pathways regulating the longitudinal acquisition of cocaine self-administration in a panel of inbred and recombinant inbred mice.Cell reports · 2023Article
- L-GIREMI uncovers RNA editing sites in long-read RNA-seq.Genome biology · 2023Article
- Genome-wide profiling of rice Double-stranded RNA-Binding Protein 1-associated RNAs by targeted RNA editing.Plant physiology · 2023Article
- Widespread RNA hypoediting in schizophrenia and its relevance to mitochondrial function.Science advances · 2023Article
- Epitranscriptome Analysis of Oxidative Stressed Retinal Epithelial Cells Depicted a Possible RNA Editing Landscape of Retinal Degeneration.Antioxidants (Basel, Switzerland) · 2022Article
- Article
- Atlas of RNA editing events affecting protein expression in aged and Alzheimer's disease human brain tissue.Nature communications · 2021Article
- Extracellular microRNA 3' end modification across diverse body fluids.Epigenetics · 2021Article
- Review
- Long-term maturation of human cortical organoids matches key early postnatal transitions.Nature neuroscience · 2021Article
- Modern Approaches for Transcriptome Analyses in Plants.Advances in experimental medicine and biology · 2021Article
- RNA editing in cancer impacts mRNA abundance in immune response pathways.Genome biology · 2020Article
- Non-canonical RNA-DNA differences and other human genomic features are enriched within very short tandem repeats.PLoS computational biology · 2020Article
- Modulator-Dependent RBPs Changes Alternative Splicing Outcomes in Kidney Cancer.Frontiers in genetics · 2020Article
- MIRIA: a webserver for statistical, visual and meta-analysis of RNA editing data in mammals.BMC bioinformatics · 2019Article
- Article
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3 authors.
Funding
Abstract
RNA-sequencing (RNA-Seq) technologies hold enormous promise for novel discoveries in genomics and transcriptomics. In the past year, a surge of reports has analyzed RNA-Seq data to gain a global view of the RNA editome. Opposing results have been presented, giving rise to extensive debate surrounding one of the first such studies in which a daunting list of all 12 types of RNA-DNA differences (RDDs) were identified. Although a consensus is forming that some of the initial "paradigm-shifting" results of this study may be questionable, recent reports on this topic differed in terms of the number and relative abundance of each type of RDD. Many outstanding issues exist, most importantly, the choice of bioinformatic approaches. Here we discuss the critical data analysis and experimental design issues of such studies to enable improved systematic investigation of the largely unexplored frontier of single-nucleotide variants in RNA.
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Registered trials
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