ArticleNature2013
The structure of the KtrAB potassium transporter.
Article in Nature, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 113 citations in OpenAlex.
- Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- A short intrinsically disordered region at KtrB's N-terminus facilitates allosteric regulation of KNature communications · 2025Article
- Genome-wide high-throughput transposon mutagenesis unveils key factors for acidic pH adaptation ofMicrobiology (Reading, England) · 2025Article
- Structural basis and synergism of ATP and NaNature communications · 2024Article
- c-di-AMP determines the hierarchical organization of bacterial RCK proteins.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Structural insights into ion selectivity and transport mechanisms of Oryza sativa HKT2;1 and HKT2;2/1 transporters.Nature plants · 2024Article
- Inverse regulation of SOS1 and HKT1 protein localization and stability by SOS3/CBL4 inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Membrane Targeted Azobenzene Drives Optical Modulation of Bacterial Membrane Potential.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Dimerisation of the Yeast KInternational journal of molecular sciences · 2022Article
- Root Transcriptional and Metabolic Dynamics Induced by the Plant Growth Promoting Rhizobacterium (PGPR)Plants (Basel, Switzerland) · 2022Article
- Article
- Assembly and Analysis of Cell-Scale Membrane Envelopes.Journal of chemical information and modeling · 2022Article
- Mechanism of high affinity potassium transporter (HKT) towards improved crop productivity in saline agricultural lands.3 Biotech · 2022Review
- Unappreciated Roles for KTrends in microbiology · 2021Review
- Deciphering ion transport and ATPase coupling in the intersubunit tunnel of KdpFABC.Nature communications · 2021Article
- Molecular Mechanisms for Bacterial Potassium Homeostasis.Journal of molecular biology · 2021Review
- Beyond Homeostasis: Potassium and Pathogenesis during Bacterial Infections.Infection and immunity · 2021Review
- Pore-forming transmembrane domains control ion selectivity and selectivity filter conformation in the KirBac1.1 potassium channel.The Journal of general physiology · 2021Article
- c-di-AMP-Regulated KInfection and immunity · 2021Article
- Plant HKT Channels: An Updated View on Structure, Function and Gene Regulation.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In bacteria, archaea, fungi and plants the Trk, Ktr and HKT ion transporters are key components of osmotic regulation, pH homeostasis and resistance to drought and high salinity. These ion transporters are functionally diverse: they can function as Na(+) or K(+) channels and possibly as cation/K(+) symporters. They are closely related to potassium channels both at the level of the membrane protein and at the level of the cytosolic regulatory domains. Here we describe the crystal structure of a Ktr K(+) transporter, the KtrAB complex from Bacillus subtilis. The structure shows the dimeric membrane protein KtrB assembled with a cytosolic octameric KtrA ring bound to ATP, an activating ligand. A comparison between the structure of KtrAB-ATP and the structures of the isolated full-length KtrA protein with ATP or ADP reveals a ligand-dependent conformational change in the octameric ring, raising new ideas about the mechanism of activation in these transporters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.