ArticleNature2013
Gating of the TrkH ion channel by its associated RCK protein TrkA.
Article in Nature, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
63 citing papers in PubMed, 99 citations in OpenAlex.
- Mechanism of Kch activation by ZnPNAS nexus · 2026Article
- Green-Synthesized vs. Chemical Silver Nanoparticles: A Comparative Study onMicroorganisms · 2026Article
- Genetic evidence for a periplasmic protein as a third component for a subset of NtrYX family two-component systems.Journal of bacteriology · 2026Article
- TrkA ofMicrobiology (Reading, England) · 2025Article
- Natranaerobius thermophilus: an anaerobic, polyextremophilic microorganism with unique properties and adaptive mechanisms.Extremophiles : life under extreme conditions · 2025Review
- A short intrinsically disordered region at KtrB's N-terminus facilitates allosteric regulation of KNature communications · 2025Article
- Evolutionary trajectory of bacterial resistance to antibiotics and antimicrobial peptides inmSystems · 2025Article
- The chloroplast-located HKT transporter plays an important role in fertilization and development in Physcomitrium patens.The Plant journal : for cell and molecular biology · 2025Article
- Bacterial cell volume regulation and the importance of cyclic di-AMP.Microbiology and molecular biology reviews : MMBR · 2024Review
- Structure and mechanism of the KNature communications · 2024Article
- The polyextremophileApplied and environmental microbiology · 2024Article
- Structural basis and synergism of ATP and NaNature communications · 2024Article
- Transcriptome fine-mapping inmBio · 2024Article
- Structural insights into ion selectivity and transport mechanisms of Oryza sativa HKT2;1 and HKT2;2/1 transporters.Nature plants · 2024Article
- The thylakoid proton antiporter KEA3 regulates photosynthesis in response to the chloroplast energy status.Nature communications · 2024Article
- The role of bacterial transport systems in the removal of host antimicrobial peptides in Gram-negative bacteria.FEMS microbiology reviews · 2022Review
- The allosteric gating mechanism of the MthK channel.National science review · 2022Article
- Metabolic tuning of a stable microbial community in the surface oligotrophic Indian Ocean revealed by integrated meta-omics.Marine life science & technology · 2022Article
- Impaired photoprotection in Phaeodactylum tricornutum KEA3 mutants reveals the proton regulatory circuit of diatoms light acclimation.The New phytologist · 2022Article
- Mechanism of high affinity potassium transporter (HKT) towards improved crop productivity in saline agricultural lands.3 Biotech · 2022Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
TrkH belongs to a superfamily of K(+) transport proteins required for growth of bacteria in low external K(+) concentrations. The crystal structure of TrkH from Vibrio parahaemolyticus showed that TrkH resembles a K(+) channel and may have a gating mechanism substantially different from K(+) channels. TrkH assembles with TrkA, a cytosolic protein comprising two RCK (regulate the conductance of K(+)) domains, which are found in certain K(+) channels and control their gating. However, fundamental questions on whether TrkH is an ion channel and how it is regulated by TrkA remain unresolved. Here we show single-channel activity of TrkH that is upregulated by ATP via TrkA. We report two structures of the tetrameric TrkA ring, one in complex with TrkH and one in isolation, in which the ring assumes two markedly different conformations. These results suggest a mechanism for how ATP increases TrkH activity by inducing conformational changes in TrkA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.