ReviewTrends in biochemical sciences2013
Opioid receptors: toward separation of analgesic from undesirable effects.
Review in Trends in biochemical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Structural dynamics of kappa opioid receptor interactions with β-arrestin 1.Nature communications · 2026Article
- Structural basis for ligand promiscuity and high signaling activity of Kaposi's Sarcoma-associated Herpesvirus-encoded GPCR.Nature communications · 2025Article
- Molecular Anatomy of Synaptic and Extrasynaptic Neurotransmission Between Nociceptive Primary Afferents and Spinal Dorsal Horn Neurons.International journal of molecular sciences · 2025Review
- N-substituted tetrahydro-beta-carboline as mu-opioid receptors ligands: in silico study; molecular docking, ADMET and molecular dynamics approach.Molecular diversity · 2024Article
- CYX-5, a G-protein biassed MOP receptor agonist, DOP receptor antagonist and KOP receptor agonist, evokes constipation but not respiratory depression relative to morphine in rats.Pharmacological reports : PR · 2023Article
- Coordinated activity of a central pathway drives associative opioid analgesic tolerance.Science advances · 2023Article
- Toward Composite Pain Biomarkers of Neuropathic Pain-Focus on Peripheral Neuropathic Pain.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- Hydrogen Sulfide Inhibits Inflammatory Pain and Enhances the Analgesic Properties of Delta Opioid Receptors.Antioxidants (Basel, Switzerland) · 2021Article
- From Pharmacology to Physiology: Endocrine Functions of μ-Opioid Receptor Networks.Trends in endocrinology and metabolism: TEM · 2021Review
- Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site.eLife · 2021Article
- Peripherally Acting Opioids in Orofacial Pain.Frontiers in neuroscience · 2021Review
- Design, Synthesis and Functional Analysis of Cyclic Opioid Peptides with Dmt-Tic Pharmacophore.Molecules (Basel, Switzerland) · 2020Article
- Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists.Science advances · 2019Article
- [Pain inhibition by opioids-new concepts].Schmerz (Berlin, Germany) · 2019Review
- Signalling in response to sub-picomolar concentrations of active compounds: Pushing the boundaries of GPCR sensitivity.British journal of pharmacology · 2019Review
- Effect of sec-O-glucosylhamaudol on mechanical allodynia in a rat model of postoperative pain.The Korean journal of pain · 2019Article
- Acute Administration of Desformylflustrabromine Relieves Chemically Induced Pain in CD-1 Mice.Molecules (Basel, Switzerland) · 2019Article
- [Pain inhibition by opioids-new concepts].Der Anaesthesist · 2019Review
- Dynamic lateral organization of opioid receptors (kappa, muTraffic (Copenhagen, Denmark) · 2018Article
- Development of an AmpliSeqFrontiers in pharmacology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The use of opioid analgesics for pain has always been hampered by their many side effects; in particular, the addictive liability associated with chronic use. Recently, attempts to develop analgesic agents with reduced side effects have targeted either the putative opioid receptor splice variants or the receptor hetero-oligomers. This review discusses the potential for receptor splice variant- and the hetero-oligomer-based discovery of new opioid analgesics. We also examine an alternative approach of using receptor mutants for pain management. Finally, we discuss the role of the biased agonism observed and the recently reported opioid receptor crystal structures in guiding the future development of opioid analgesics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.