Evidence map›Paper›PMID 23597789›Full record

ArticleCurrent opinion in microbiology2013

Fungal cell wall dynamics and infection site microenvironments: signal integration and infection outcome.

Kelly M Shepardson, Robert A Cramer

Open access · greenAbstract read
In one paragraph

Article in Current opinion in microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. mBio · 2017
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kelly M ShepardsonGeisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
Robert A Cramer
Dartmouth College · US

Funding

Hypoxia Adaptation and Fungal Virulence of Aspergillus fumigatusR01AI081838 · NIAID · MONTANA STATE UNIVERSITY - BOZEMAN · PI CRAMER, ROBERT ANDREW · 2009 to 2017
$2.9M
RENAL FUNCTION AND DISEASET32DK007301 · NIDDK · DARTMOUTH COLLEGE · PI STANTON, BRUCE A. · 1986 to 2014
$2.3M
NIAID NIH HHS L40 AI084526NIAID NIH HHS R01 AI081838NIAID NIH HHS R01AI81838NIDDK NIH HHS 5T32DK007301NIDDK NIH HHS T32 DK007301
6 · The paper itself

Abstract

Upon entrance into the host, fungi encounter a myriad of host effector products and microenvironments that they sense and adapt to for survival. Alterations of the structure and composition of the cell wall is a major fungal adaptation mechanism to evade these environments. Here we discuss recent findings of host-microenvironmental induced fungal cell wall changes, including structure, composition, and protein content, and their effects on host immune responses. A take home message from these recent studies is an emerging understanding of how integration of multiple signals, of both fungal and host responses to dynamic infection site microenvironments, determines outcomes of infection. A challenge moving forward is to further understand these mechanisms and harness them for therapeutic benefit.

Indexed as

Host-Pathogen InteractionsSignal TransductionAnimalsCell WallFungiHumansMammalsMycoses

Identifiers

PMID23597789
PMCPMC3755087
OpenAlexW1991916224

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.