ArticlePhytochemistry2013
Accurate mass-time tag library for LC/MS-based metabolite profiling of medicinal plants.
Article in Phytochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Antioxidant and Antidiabetic Activity of the Bulb Extract ofAntioxidants (Basel, Switzerland) · 2026Article
- CUL3Science advances · 2026Article
- Quantitative ambient mass spectrometry imaging in plants: A perspective on challenges and future applications.Current opinion in plant biology · 2025Review
- Development of a Tandem Mass Spectral Library for the Detection of Triterpenoids in Plant Metabolome Based on Reference Standards.Plants (Basel, Switzerland) · 2024Article
- Altered Metabolism in Knockdown Lines of Two HXXXD/BAHD Acyltransferases During Wound Healing in Potato Tubers.Plants (Basel, Switzerland) · 2024Article
- Natural Products Dereplication: Databases and Analytical Methods.Progress in the chemistry of organic natural products · 2024Review
- Differential Accumulation of Metabolites and Transcripts Related to Flavonoid, Styrylpyrone, and Galactolipid Biosynthesis inMetabolites · 2022Article
- The Botanical, Chemical and Ethnobotanical Diversity of Southern African Lamiaceae.Molecules (Basel, Switzerland) · 2021Review
- RP-UHPLC-MS Chemical Profiling, Biological and In Silico Docking Studies to Unravel the Therapeutic Potential ofBiomolecules · 2021Article
- Evaluation of the Phytochemical, Antioxidant, Enzyme Inhibition, and Wound Healing Potential ofFrontiers in pharmacology · 2021Article
- Biochemical characterization of acyl activating enzymes for side chain moieties of Taxol and its analogs.The Journal of biological chemistry · 2020Article
- Article
- Identification of small molecules using accurate mass MS/MS search.Mass spectrometry reviews · 2018Review
- Biosynthesis of Diterpenoids inPlant physiology · 2017Article
- From chromatogram to analyte to metabolite. How to pick horses for courses from the massive web resources for mass spectral plant metabolomics.GigaScience · 2017Review
- Integrative Approaches for the Identification and Localization of Specialized Metabolites in Tripterygium Roots.Plant physiology · 2017Article
- The WEIZMASS spectral library for high-confidence metabolite identification.Nature communications · 2016Article
- NMR spectroscopic search module for Spektraris, an online resource for plant natural product identification--Taxane diterpenoids from Taxus × media cell suspension cultures as a case study.Phytochemistry · 2015Article
- Analysis of phenolic and cyclic compounds in plants using derivatization techniques in combination with GC-MS-based metabolite profiling.Molecules (Basel, Switzerland) · 2015Article
- Open-access metabolomics databases for natural product research: present capabilities and future potential.Frontiers in bioengineering and biotechnology · 2015Review
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
We report the development and testing of an accurate mass-time (AMT) tag approach for the LC/MS-based identification of plant natural products (PNPs) in complex extracts. An AMT tag library was developed for approximately 500 PNPs with diverse chemical structures, detected in electrospray and atmospheric pressure chemical ionization modes (both positive and negative polarities). In addition, to enable peak annotations with high confidence, MS/MS spectra were acquired with three different fragmentation energies. The LC/MS and MS/MS data sets were integrated into online spectral search tools and repositories (Spektraris and MassBank), thus allowing users to interrogate their own data sets for the potential presence of PNPs. The utility of the AMT tag library approach is demonstrated by the detection and annotation of active principles in 27 different medicinal plant species with diverse chemical constituents.
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Registered trials
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