ArticleDevelopmental cell2013
Regional modulation of a stochastically expressed factor determines photoreceptor subtypes in the Drosophila retina.
Article in Developmental cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 47 citations in OpenAlex.
- Cellular innovations and diversity in the lepidopteran compound eye.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- Cell fate ratios are encoded by transcriptional dynamics in the Drosophila retina.Current biology : CB · 2025Article
- Genome-Wide Association Study and transcriptome analysis reveals a complex gene network that regulates opsin gene expression and cell fate determination inbioRxiv : the preprint server for biology · 2024Article
- Transcriptional priming and chromatin regulation during stochastic cell fate specification.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Functional opsin patterning for Drosophila color vision is established through signaling pathways in adjacent object-detection neurons.Development (Cambridge, England) · 2024Article
- Activating and repressing gene expression between chromosomes during stochastic fate specification.Cell reports · 2023Article
- Insect opsins and evo-devo: what have we learned in 25 years?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Temporally dynamic antagonism between transcription and chromatin compaction controls stochastic photoreceptor specification in flies.Developmental cell · 2022Article
- The power of the (imperfect) palindrome: Sequence-specific roles of palindromic motifs in gene regulation.BioEssays : news and reviews in molecular, cellular and developmental biology · 2022Review
- Review
- A combinatorial cis-regulatory logic restricts color-sensing Rhodopsins to specific photoreceptor subsets in Drosophila.PLoS genetics · 2021Article
- Interdependent regulation of stereotyped and stochastic photoreceptor fates in the fly eye.Developmental biology · 2021Article
- Identification of Genes Involved in the Differentiation of R7y and R7p Photoreceptor Cells inG3 (Bethesda, Md.) · 2020Article
- Gene regulatory networks during the development of the Drosophila visual system.Current topics in developmental biology · 2020Review
- Article
- Characterization of Button Loci that Promote Homologous Chromosome Pairing and Cell-Type-Specific Interchromosomal Gene Regulation.Developmental cell · 2019Article
- HLH-2/E2A Expression Links Stochastic and Deterministic Elements of a Cell Fate Decision during C. elegans Gonadogenesis.Current biology : CB · 2019Article
- Hippo signalling during development.Development (Cambridge, England) · 2019Review
- Buffering and Amplifying Transcriptional Noise During Cell Fate Specification.Frontiers in genetics · 2018Review
- Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Stochastic mechanisms are sometimes utilized to diversify cell fates, especially in nervous systems. In the Drosophila retina, stochastic expression of the PAS-bHLH transcription factor Spineless (Ss) controls photoreceptor subtype choice. In one randomly distributed subset of R7 photoreceptors, Ss activates Rhodopsin4 (Rh4) and represses Rhodopsin3 (Rh3); counterparts lacking Ss express Rh3 and repress Rh4. In the dorsal third region of the retina, the Iroquois Complex transcription factors induce Rh3 in Rh4-expressing R7s. Here, we show that Ss levels are controlled in a binary on/off manner throughout the retina yet are attenuated in the dorsal third region to allow Rh3 coexpression with Rh4. Whereas the sensitivity of rh3 repression to differences in Ss levels generates stochastic and regionalized patterns, the robustness of rh4 activation ensures its stochastic expression throughout the retina. Our findings show how stochastic and regional inputs are integrated to control photoreceptor subtype specification in the Drosophila retina.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.