ArticleBMC medicine2013
Integrating sepsis management recommendations into clinical care guidelines for district hospitals in resource-limited settings: the necessity to augment new guidelines with future research.
Article in BMC medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Early Recognition and Management of Sepsis in Sub-Saharan African Adults: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2018Pooled it
- Clinical Outcomes for Emergency Department Presentations of Sepsis Managed on a Clinical Pathway: A Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2026Review
- The Global Burden of Sepsis and Septic Shock.Epidemiologia (Basel, Switzerland) · 2024Review
- The Universal Vital Assessment (UVA) score at 6 hours post-resuscitation predicts mortality in hospitalized adults with severe sepsis in Mbarara, Uganda.PLOS global public health · 2024Article
- Outcomes of World Health Organization-defined Severe Respiratory Distress without Shock in Adults in Sub-Saharan Africa.American journal of respiratory and critical care medicine · 2024Article
- Effect of a tailored sepsis treatment protocol on patient outcomes in the Tikur Anbessa Specialized Hospital, Ethiopia: results of an interrupted time series analysis.Implementation science : IS · 2022Article
- Challenges and Solutions in translating sepsis guidelines into practice in resource-limited settings.Translational pediatrics · 2021Review
- Improving sepsis care in Africa: an opportunity for change?The Pan African medical journal · 2021Article
- qSOFA as a predictor of ICU outcomes in a resource-limited setting in KwaZulu-Natal Province, South Africa.The Southern African journal of critical care : the official journal of the Critical Care Society · 2020Article
- The global burden of sepsis: barriers and potential solutions.Critical care (London, England) · 2018Review
- Development of a short course on management of critically ill patients with acute respiratory infection and impact on clinician knowledge in resource-limited intensive care units.Influenza and other respiratory viruses · 2018Article
- The Emergency Department Crash Cart: A systematic review and suggested contents.World journal of emergency medicine · 2018Review
- Observational
- Patient Characteristics, Management, and Predictors of Outcome from Severe Community-Onset Staphylococcal Sepsis in Northeast Thailand: A Prospective Multicenter Study.The American journal of tropical medicine and hygiene · 2017Observational
- The Assessment, Evaluation, and Management of the Critically Ill Child in Resource-Limited International Settings.Journal of pediatric intensive care · 2017Review
- Goal directed therapy for suspected acute bacterial meningitis in adults and adolescents in sub-Saharan Africa.PloS one · 2017Article
- Article
- Inverting the pyramid: increasing awareness of mycobacterial sepsis in sub-Saharan Africa.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2015Article
- Severely deranged vital signs as triggers for acute treatment modifications on an intensive care unit in a low-income country.BMC research notes · 2015Observational
- Vital Signs Directed Therapy: Improving Care in an Intensive Care Unit in a Low-Income Country.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Several factors contribute to the high mortality attributed to severe infections in resource-limited settings. While improvements in survival and processes of care have been made in high-income settings among patients with severe conditions, such as sepsis, guidelines necessary for achieving these improvements may lack applicability or have not been tested in resource-limited settings. The World Health Organization's recent publication of the Integrated Management of Adolescent and Adult Illness District Clinician Manual provides details on how to optimize management of severely ill, hospitalized patients in such settings, including specific guidance on the management of patients with septic shock and respiratory failure without shock. This manuscript provides the context, process and underpinnings of these sepsis guidelines. In light of the current deficits in care and the limitations associated with these guidelines, the authors propose implementing these standardized best practice guidelines while using them as a foundation for sepsis research undertaken in, and directly relevant to, resource-limited settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.