ArticleBMC biology2013
Radial glial cells play a key role in echinoderm neural regeneration.
Article in BMC biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 65 citations in OpenAlex.
- Echinoderm Radial Glia-Like Cells Express Vertebrate Glial Markers.The Journal of comparative neurology · 2025Article
- Evolution of Astrocyte-Neuron Interactions Across Species.Advances in neurobiology · 2024Review
- Regeneration of starfish radial nerve cord restores animal mobility and unveils a new coelomocyte population.Cell and tissue research · 2023Article
- Ethical Considerations for Echinoderms: New Initiatives in Welfare.Animals : an open access journal from MDPI · 2023Review
- Echinoderm radial glia in adult cell renewal, indeterminate growth, and regeneration.Frontiers in neural circuits · 2023Review
- The Stress Response of the Holothurian Central Nervous System: A Transcriptomic Analysis.International journal of molecular sciences · 2022Article
- A subterminal growth zone at arm tip likely underlies life-long indeterminate growth in brittle stars.Frontiers in zoology · 2022Article
- Radial glia and radial glia-like cells: Their role in neurogenesis and regeneration.Frontiers in neuroscience · 2022Review
- Characterization of Two Novel EF-Hand Proteins Identifies a Clade of Putative CaJournal of bioinformatics and systems biology : Open access · 2022Article
- Dedifferentiation of radial glia-like cells is observed in in vitro explants of holothurian radial nerve cord.Journal of neuroscience methods · 2021Article
- Article
- Regeneration in Echinoderms: Molecular Advancements.Frontiers in cell and developmental biology · 2021Review
- Developmental Biology in Central America, the northern region of South America and the Caribbean.The International journal of developmental biology · 2021Review
- Neurons and Glia Cells in Marine Invertebrates: An Update.Frontiers in neuroscience · 2020Review
- Beyond Adult Stem Cells: Dedifferentiation as a Unifying Mechanism Underlying Regeneration in Invertebrate Deuterostomes.Frontiers in cell and developmental biology · 2020Review
- Radial Glia in Echinoderms.Developmental neurobiology · 2019Review
- Expression of the neuropeptide SALMFamide-1 during regeneration of the seastar radial nerve cord following arm autotomy.Proceedings. Biological sciences · 2019Article
- Analysis of sea star larval regeneration reveals conserved processes of whole-body regeneration across the metazoa.BMC biology · 2019Article
- Comparative Phospho- and Acetyl Proteomics Analysis of Posttranslational Modifications Regulating Intestine Regeneration in Sea Cucumbers.Frontiers in physiology · 2018Article
- Connecting the nervous and the immune systems in evolution.Communications biology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundUnlike the mammalian central nervous system (CNS), the CNS of echinoderms is capable of fast and efficient regeneration following injury and constitutes one of the most promising model systems that can provide important insights into evolution of the cellular and molecular events involved in neural repair in deuterostomes. So far, the cellular mechanisms of neural regeneration in echinoderm remained obscure. In this study we show that radial glial cells are the main source of new cells in the regenerating radial nerve cord in these animals.
resultsWe demonstrate that radial glial cells of the sea cucumber Holothuria glaberrima react to injury by dedifferentiation. Both glia and neurons undergo programmed cell death in the lesioned CNS, but it is the dedifferentiated glial subpopulation in the vicinity of the injury that accounts for the vast majority of cell divisions. Glial outgrowth leads to formation of a tubular scaffold at the growing tip, which is later populated by neural elements. Most importantly, radial glial cells themselves give rise to new neurons. At least some of the newly produced neurons survive for more than 4 months and express neuronal markers typical of the mature echinoderm CNS.
conclusionsA hypothesis is formulated that CNS regeneration via activation of radial glial cells may represent a common capacity of the Deuterostomia, which is not invoked spontaneously in higher vertebrates, whose adult CNS does not retain radial glial cells. Potential implications for biomedical research aimed at finding the cure for human CNS injuries are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.