ArticleReproductive biology and endocrinology : RB&E2013
Maternal diabetes causes abnormal dynamic changes of endoplasmic reticulum during mouse oocyte maturation and early embryo development.
Article in Reproductive biology and endocrinology : RB&E, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Endoplasmic reticulum in oocytes: spatiotemporal distribution and function.Journal of assisted reproduction and genetics · 2023Pooled it
- The potential protective effects of curcumin on the diabetic ovary: Experimental and molecular approaches.Histology and histopathology · 2025Review
- Nicotinamide riboside supplementation protects against maternal diabetes-associated decline in oocyte quality.Reproduction (Cambridge, England) · 2025Article
- FMNL2 regulates actin for endoplasmic reticulum and mitochondria distribution in oocyte meiosis.eLife · 2024Article
- Ultra-Fast Vitrification: Minimizing the Toxicity of Cryoprotective Agents and Osmotic Stress in Mouse Oocyte Cryopreservation.International journal of molecular sciences · 2024Article
- Nuclear-cytoplasmic asynchrony in oocyte maturation caused by TUBB8 variants via impairing microtubule function: a novel pathogenic mechanism.Reproductive biology and endocrinology : RB&E · 2023Article
- Maternal Preconception Glucose Homeostasis and Insulin Resistance Are Associated with Singleton and Twin Birthweight of Neonates Conceived by PCOS Women Undergoing IVF/ICSI Cycles.Journal of clinical medicine · 2023Article
- DDX1 vesicles control calcium-dependent mitochondrial activity in mouse embryos.Nature communications · 2022Article
- Diabetic Uterine Environment Leads to Disorders in Metabolism of Offspring.Frontiers in cell and developmental biology · 2021Article
- Bisphenol A Exposure Disrupts Organelle Distribution and Functions During Mouse Oocyte Maturation.Frontiers in cell and developmental biology · 2021Article
- Involvement of SIRT3-GSK3β deacetylation pathway in the effects of maternal diabetes on oocyte meiosis.Cell proliferation · 2021Article
- Poorly-Controlled Type 1 Diabetes Mellitus Impairs LH-LHCGR Signaling in the Ovaries and Decreases Female Fertility in Mice.Yonsei medical journal · 2019Article
- SIRT2 Inhibition Results in Meiotic Arrest, Mitochondrial Dysfunction, and Disturbance of Redox Homeostasis during Bovine Oocyte Maturation.International journal of molecular sciences · 2019Article
- Article
- Type 2 diabetes increases oocyte mtDNA mutations which are eliminated in the offspring by bottleneck effect.Reproductive biology and endocrinology : RB&E · 2018Article
- Epigenetics and developmental origins of diabetes: correlation or causation?American journal of physiology. Endocrinology and metabolism · 2018Review
- Cumulus cell mitochondrial activity in relation to body mass index in women undergoing assisted reproductive therapy.BBA clinical · 2017Article
- The status of diabetic embryopathy.Upsala journal of medical sciences · 2016Review
- Metabolic control of oocyte development: linking maternal nutrition and reproductive outcomes.Cellular and molecular life sciences : CMLS · 2015Review
- Epigenetics and life-long consequences of an adverse nutritional and diabetic intrauterine environment.Reproduction (Cambridge, England) · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe adverse effects of maternal diabetes on oocyte maturation and embryo development have been reported.
methodsIn this study, we used time-lapse live cell imaging confocal microscopy to investigate the dynamic changes of ER and the effects of diabetes on the ER's structural dynamics during oocyte maturation, fertilization and early embryo development.
resultsWe report that the ER first became remodeled into a dense ring around the developing MI spindle, and then surrounded the spindle during migration to the cortex. ER reorganization during mouse early embryo development was characterized by striking localization around the pronuclei in the equatorial section, in addition to larger areas of fluorescence deeper within the cytoplasm. In contrast, in diabetic mice, the ER displayed a significantly higher percentage of homogeneous distribution patterns throughout the entire ooplasm during oocyte maturation and early embryo development. In addition, a higher frequency of large ER aggregations was detected in GV oocytes and two cell embryos from diabetic mice.
conclusionsThese results suggest that the diabetic condition adversely affects the ER distribution pattern during mouse oocyte maturation and early embryo development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.