ArticleFrontiers in oncology2013
Stem cell control, oscillations, and tissue regeneration in spatial and non-spatial models.
Article in Frontiers in oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Licensing and niche competition in spermatogenesis: mathematical models suggest complementary regulation of tissue maintenance.Development (Cambridge, England) · 2025Article
- Mathematical modelling of stem and progenitor cell dynamics during ruxolitinib treatment of patients with myeloproliferative neoplasms.Frontiers in immunology · 2024Article
- Mathematical modelling identifies conditions for maintaining and escaping feedback control in the intestinal epithelium.Scientific reports · 2022Article
- Effect of feedback regulation on stem cell fractions in tissues and tumors: Understanding chemoresistance in cancer.Journal of theoretical biology · 2021Article
- Tracing the Dynamics of Stem Cell Fate.Cold Spring Harbor perspectives in biology · 2020Review
- Modelling stem cell ageing: a multi-compartment continuum approach.Royal Society open science · 2020Article
- Development of Aspirin-Inducible Biosensors inApplied and environmental microbiology · 2019Article
- A computational model of feedback-mediated hematopoietic stem cell differentiation in vitro.PloS one · 2019Article
- Effect of cellular de-differentiation on the dynamics and evolution of tissue and tumor cells in mathematical models with feedback regulation.Journal of theoretical biology · 2018Article
- Multi-scale modeling of APC and [Formula: see text]-catenin regulation in the human colonic crypt.Journal of mathematical biology · 2018Article
- Cellular Hierarchy as a Determinant of Tumor Sensitivity to Chemotherapy.Cancer research · 2017Article
- Near Equilibrium Calculus of Stem Cells in Application to the Airway Epithelium Lineage.PLoS computational biology · 2016Article
- An agent-based model of cancer stem cell initiated avascular tumour growth and metastasis: the effect of seeding frequency and location.Journal of the Royal Society, Interface · 2014Article
- Robustness of differentiation cascades with symmetric stem cell division.Journal of the Royal Society, Interface · 2014Article
- Clonal selection and therapy resistance in acute leukaemias: mathematical modelling explains different proliferation patterns at diagnosis and relapse.Journal of the Royal Society, Interface · 2014Article
- Interactions and tradeoffs between cell recruitment, proliferation, and differentiation affect CNS regeneration.Biophysical journal · 2014Article
- Simulating cancer: computational models in oncology.Frontiers in oncology · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Normal human tissue is organized into cell lineages, in which the highly differentiated mature cells that perform tissue functions are the end product of an orderly tissue-specific sequence of divisions that start with stem cells or progenitor cells. Tissue homeostasis and effective regeneration after injuries requires tight regulation of these cell lineages and feedback loops play a fundamental role in this regard. In particular, signals secreted from differentiated cells that inhibit stem cell division and stem cell self-renewal are important in establishing control. In this article we study in detail the cell dynamics that arise from this control mechanism. These dynamics are fundamental to our understanding of cancer, given that tumor initiation requires an escape from tissue regulation. Knowledge on the processes of cellular control can provide insights into the pathways that lead to deregulation and consequently cancer development.
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