ArticlePloS one2013
Broad spectrum of mimiviridae virophage allows its isolation using a mimivirus reporter.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 64 citations in OpenAlex.
- Pantanal virophage: a new virophage species associated with a moumouvirus and a transpoviron, expanding the genusJournal of virology · 2026Article
- Uncovering novel virophages and giant viruses in high-altitude Lake Namtso: diversity and evolution of host-virus-virophage tripartite interaction systems.Archives of microbiology · 2026Article
- Microalga-virus-virophage coculture reveals co-infection of multi-virophages with a giant virus.Archives of virology · 2026Article
- Sputnik virophage disrupts the transcriptional regulation of its host giant virus.Journal of virology · 2025Article
- The polinton-like supergroup of viruses: evolution, molecular biology, and taxonomy.Microbiology and molecular biology reviews : MMBR · 2024Review
- Virophages, Satellite Viruses, Virophage Replication and Its Effects and Virophage Defence Mechanisms for Giant Virus Hosts and Giant Virus Defence Systems against Virophages.International journal of molecular sciences · 2024Review
- Virophages Found in Viromes from Lake Baikal.Biomolecules · 2023Article
- Virophages-Known and Unknown Facts.Viruses · 2023Review
- Large-scale invasion of unicellular eukaryotic genomes by integrating DNA viruses.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Updated Virophage Taxonomy and Distinction from Polinton-like Viruses.Biomolecules · 2023Article
- A virophage cross-species infection through mutant selection represses giant virus propagation, promoting host cell survival.Communications biology · 2020Article
- Novel Cell-Virus-Virophage Tripartite Infection Systems Discovered in the Freshwater Lake Dishui Lake in Shanghai, China.Journal of virology · 2020Article
- Exploration of the propagation of transpovirons within Mimiviridae reveals a unique example of commensalism in the viral world.The ISME journal · 2020Article
- Diversity, evolution, and classification of virophages uncovered through global metagenomics.Microbiome · 2019Article
- Giant virus vs amoeba: fight for supremacy.Virology journal · 2019Review
- Review
- Virophages of Giant Viruses: An Update at Eleven.Viruses · 2019Review
- Review
- Guarani Virophage, a New Sputnik-Like Isolate From a Brazilian Lake.Frontiers in microbiology · 2019Article
- Role of the R349 Gene and Its Repeats in the MIMIVIRE Defense System.Frontiers in microbiology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The giant virus Mimiviridae family includes 3 groups of viruses: group A (includes Acanthamoeba polyphaga Mimivirus), group B (includes Moumouvirus) and group C (includes Megavirus chilensis). Virophages have been isolated with both group A Mimiviridae (the Mamavirus strain) and the related Cafeteria roenbergensis virus, and they have also been described by bioinformatic analysis of the Phycodnavirus. Here, we found that the first two strains of virophages isolated with group A Mimiviridae can multiply easily in groups B and C and play a role in gene transfer among these virus subgroups. To isolate new virophages and their Mimiviridae host in the environment, we used PCR to identify a sample with a virophage and a group C Mimiviridae that failed to grow on amoeba. Moreover, we showed that virophages reduce the pathogenic effect of Mimivirus (plaque formation), establishing its parasitic role on Mimivirus. We therefore developed a co-culture procedure using Acanthamoeba polyphaga and Mimivirus to recover the detected virophage and then sequenced the virophage's genome. We present this technique as a novel approach to isolating virophages. We demonstrated that the newly identified virophages replicate in the viral factories of all three groups of Mimiviridae, suggesting that the spectrum of virophages is not limited to their initial host.
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