ArticlePloS one2013
The association of 25 hydroxyvitamin D and parathyroid hormone with metabolic syndrome in two ethnic groups in South Africa.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Prevalence of the metabolic syndrome in African populations: A systematic review and meta-analysis.PloS one · 2023Pooled it
- Review: Metabolic Syndrome in Black South African Women.Ethnicity & disease · 2017Pooled it
- Maternal serum vitamin D levels and preeclampsia among Kenyan pregnant women: A matched case-control study.PloS one · 2026Article
- Prevalence of vitamin D deficiency and its association with cardiometabolic risk factors among healthcare workers in the Eastern Cape province, South Africa; cross-sectional study.Scientific reports · 2024Article
- A pilot study: relationship between Bisphenol A, Bisphenol-glucuronide and total 25 hydroxy vitamin D in maternal-child pairs in a South African population.Frontiers in endocrinology · 2024Article
- Review
- Association between circulating 25-hydroxyvitamin D and cardiometabolic risk factors in adults in rural and urban settings.Nutrition & diabetes · 2022Article
- The relationship between physical activity, body fatness and metabolic syndrome in urban South African school teachers: The sympathetic activity and ambulatory blood pressure in Africans study.African journal of primary health care & family medicine · 2022Article
- Osteoporosis in Africa-where are we now.Clinical rheumatology · 2021Review
- Calcium Intake Is Inversely Related to Risk of Obesity among American Young Adults over a 30-Year Follow-Up.The Journal of nutrition · 2021Article
- Branched-chain and aromatic amino acids and cardiometabolic risk in Black African and Asian Indian populations.Metabolomics : Official journal of the Metabolomic Society · 2020Article
- Race-specific associations of 25-hydroxyvitamin D and parathyroid hormone with cardiometabolic biomarkers among US white and black postmenopausal women.The American journal of clinical nutrition · 2020Observational
- Maternal plasma vitamin D levels and associated determinants in late pregnancy in Harare, Zimbabwe: a cross-sectional study.BMC pregnancy and childbirth · 2019Article
- High phosphate diet suppresses lipogenesis in white adipose tissue.Journal of clinical biochemistry and nutrition · 2018Article
- Racial Variations in the Markers of Mineral Bone Disorders in CKD Patients in South Africa.Kidney international reports · 2018Article
- The association of adiposity, physical fitness, vitamin D levels and haemodynamic parameters in young Saudi females.Journal of Taibah University Medical Sciences · 2018Article
- Gender specific association of parathyroid hormone and vitamin D with metabolic syndrome in population with preserved renal function.Scientific reports · 2018Article
- Special considerations for vitamin D in the south Asian population in the UK.Therapeutic advances in musculoskeletal disease · 2017Review
- Article
- Vitamin D Status and Its Consequences for Health in South Africa.International journal of environmental research and public health · 2016Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
introductionThough inconsistent, a number of studies have shown an association between vitamin D (25(OH)D) status, parathyroid hormone (PTH) and the metabolic syndrome (Met S). These have largely been carried out in Caucasians or black subjects living in high income countries. There no data on the relationship of 25(OH)D and PTH status with Met S in populations resident in Africa. The aims of this study were to evaluate if there was an association of 25(OH)D or PTH with Met S in non-Caucasian populations in South Africa, and whether these molecules explained ethnic differences in the prevalence of Met S and its individual components.
methodsWe measured anthropometry, serum 25(OH)D and PTH levels and the components of Met S, plus related metabolic variables, in 374 African and 350 Asian Indian healthy adults from the greater Johannesburg metropolitan area.
resultsMet S was diagnosed in 29% of the African and 46% of the Asian Indian subjects (p<0.0001). Subjects with Met S had higher PTH than those without Met S, (p<0.0001), whilst 25(OH)D levels were not significantly different (p = 0.50). In multivariate analysis, 25(OH)D was not associated with any components of the Met S however PTH was shown to be positively associated with systolic (p = 0.018) and diastolic (p = 0.005) blood pressures and waist circumference (p<0.0001) and negatively associated with HOMA (p = 0.0008) levels. Logistic regression analysis showed that Asian Indian ethnicity (OR 2.24; 95% CIs 1.57, 3.18; p<0.0001) and raised PTH (OR 2.48; 95% CIs 1.01, 6.08; p = 0.04; adjusted for 25(OH)D) produced an increased risk of Met S but 25(OH)D did not (OR 1.25; 95% CI 0.67, 2.24; p = 0.48).
conclusionsPlasma PTH but not 25(OH)D is an independent predictor of the Met S in African and Asian Indians in South Africa.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.