ArticleDeutsches Arzteblatt international2013
Adverse drug events in older patients admitted as an emergency: the role of potentially inappropriate medication in elderly people (PRISCUS).
Article in Deutsches Arzteblatt international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 3 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Prevalence of Use of Potentially Inappropriate Medications Among Older Adults Worldwide: A Systematic Review and Meta-Analysis.JAMA network open · 2023Pooled it
- Benefits of medication charts provided at transitions of care: a narrative systematic review.BMJ open · 2020Pooled it
- Hospital admissions due to adverse drug reactions in the elderly. A meta-analysis.European journal of clinical pharmacology · 2017Pooled it
- The efficacy of a medication review programme conducted in an emergency department.International journal of clinical pharmacy · 2019Trial
- Effects of "Fit fOR The Aged" (FORTA) on pharmacotherapy and clinical endpoints--a pilot randomized controlled study.European journal of clinical pharmacology · 2014Trial
- Trial
- Quantification of the prevalence of harms in healthcare related to drug treatment: reflections regarding the use of definitions developed for other settings to estimate the magnitude of the problem.European journal of clinical pharmacology · 2025Article
- Prevalence and factors associated with preventable drug-related emergency department visits (DREDBMC emergency medicine · 2024Article
- Drug safety in older patients with alcohol use disorder: a retrospective cohort study.Therapeutic advances in psychopharmacology · 2024Article
- Drug Safety Profiles of Geriatric Patients Referred to Consultation Psychiatry in the Emergency Department-A Retrospective Cohort Study.Journal of geriatric psychiatry and neurology · 2023Article
- Potentially Inappropriate Medications Use among Older Adults with Dyslipidaemia.Journal of clinical medicine · 2023Article
- Assessment of drug-related problems at the emergency department in older patients living with frailty: pharmacist-led medication reviews within a geriatric care team.BMC geriatrics · 2023Observational
- The impact of partnered pharmacist medication charting in the emergency department on the use of potentially inappropriate medications in older people.Frontiers in pharmacology · 2023Article
- Medication use problems among older adults at a primary care: A narrative of literature review.Aging medicine (Milton (N.S.W)) · 2022Review
- Drug-related hospital admissions in older adults: comparison of the Naranjo algorithm and an adjusted version of the Kramer algorithm.European geriatric medicine · 2022Article
- [Identification of polypharmacy-associated risks among nursing home residents].Zeitschrift fur Gerontologie und Geriatrie · 2022Article
- Patient Safety in a Box: Implementation and Evaluation of the Emergency Box in Geriatric and Parkinson Patients.Journal of clinical medicine · 2021Article
- Potentially inappropriate medication in older psychiatric patients.European journal of clinical pharmacology · 2021Article
- Quality indicators for a geriatric emergency care (GeriQ-ED) - an evidence-based delphi consensus approach to improve the care of geriatric patients in the emergency department.Scandinavian journal of trauma, resuscitation and emergency medicine · 2020Article
- Risk factors associated with drug therapy among elderly people with Alzheimer's disease: a cross-sectional study.Sao Paulo medical journal = Revista paulista de medicina · 2020Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLists of potentially inappropriate medications (PIMs) for the elderly, such as the German PRISCUS list, have been published as expert recommendations with the aim of improving drug safety for this patient group. In this study, we tried to determine how often adverse drug events occur in the emergency department and what role PRISCUS medications might play in these events.
methodsWe prospectively reviewed the medical records of 752 patients who were treated in the emergency department (ED) of a level III hospital in Germany for adverse drug events due to medication errors (MEs) and for adverse drug reactions (ADRs). The evaluation was performed in two steps by pharmacologists, clinical pharmacologists, and board-certified internists.
resultsBoth clinically important MEs and ADRs became more common with advancing age. Among the 351 patients who were over age 65, 307 (87.5%) were taking at least one medication at home. Of these 307 patients, 16.6% (95% confidence interval [CI]: 12.9-21.2%) were taking at least one PIM, as defined by the German PRISCUS list. In relative terms, PIMs were more commonly associated with ADRs or MEs than other drugs (27.0% [95% CI: 17.5-39.1% versus 15.7% [95% CI: 14.1-17.4%], Odds ratio 1.99 [95% CI: 1.23-3.52: p = 0.018), but in absolute terms ADRs and MEs involved non-PIM more often than PIM.
conclusionElderly patients more frequently suffer from ADR and from the clinical consequences of medication errors. Elderly patients taking PIMs are more likely to suffer from ADRs and MEs, even though most drug-related events are still attributable to non-PIM.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.