ArticleExperimental and therapeutic medicine2013
Effects of ultraviolet B exposure on DNA methylation in patients with systemic lupus erythematosus.
Article in Experimental and therapeutic medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- iPSCs and iPSC-derived cells as a model of human genetic and epigenetic variation.Nature communications · 2025Article
- Disentangling the Pathogenesis of Systemic Lupus Erythematosus: Close Ties between Immunological, Genetic and Environmental Factors.Medicina (Kaunas, Lithuania) · 2023Review
- UVR8 interacts with de novo DNA methyltransferase and suppresses DNA methylation in Arabidopsis.Nature plants · 2021Article
- Bioinformatics analysis of epigenetic and SNP-related molecular markers in systemic lupus erythematosus.American journal of translational research · 2021Article
- Inhibition of UVB-Induced Inflammation by Laminaria japonica Extract via Regulation of nc886-PKR Pathway.Nutrients · 2020Article
- Article
- Mechanistic insights into environmental and genetic risk factors for systemic lupus erythematosus.American journal of translational research · 2019Review
- HORMAD2 methylation-mediated epigenetic regulation of gene expression in thyroid cancer.Journal of cellular and molecular medicine · 2018Article
- Effects of Major Epigenetic Factors on Systemic Lupus ErythematosusIranian biomedical journal · 2018Review
- Drug-induced Rowell syndrome, a rare and difficult to manage disease: A case report.Experimental and therapeutic medicine · 2018Article
- Human and Murine Evidence for Mechanisms Driving Autoimmune Photosensitivity.Frontiers in immunology · 2018Review
- Epigenetics in SLE.Current rheumatology reports · 2017Review
- DNA methylation in systemic lupus erythematosus.Epigenomics · 2017Review
- Increased 5-hydroxymethylcytosine and Ten-eleven Translocation Protein Expression in Ultraviolet B-irradiated HaCaT Cells.Chinese medical journal · 2017Article
- Role of DNA Methylation on the Expression of the Anthracycline Metabolizing Enzyme AKR7A2 in Human Heart.Cardiovascular toxicology · 2016Article
- Peritoneal dialysis treatment for severe lupus nephritis patients complicated with essential organ dysfunction.Experimental and therapeutic medicine · 2015Article
- Article
- Epigenetic Aspects of Systemic Lupus Erythematosus.Rheumatology and therapy · 2015Review
- Potential of epigenetic therapies in non-cancerous conditions.Frontiers in genetics · 2014Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the effects of ultraviolet B (UVB) exposure on DNA methylation in patients with systemic lupus erythematosus (SLE) and its significance in the pathogenesis of SLE. T cells from 35 SLE patients and 21 healthy individuals were cultured and irradiated with UVB. The global DNA methylation profiles of the T cells obtained from the patients and controls following irradiation with UVB were assessed using specific monoclonal antibodies for 5-methylcytosine and analyzed quantitatively through flow cytometry. Real-time reverse transcription-polymerase chain reaction (RT-PCR) was used to analyze the levels of DNA methyltransferase 1 (DNMT1) and methyl CpG binding domain protein 2 (MBD2) in T cells from the patients and controls following UVB irradiation. Significant global DNA hypomethylation was observed in the SLE patients compared with the controls (P<0.01). The SLE patients also had significantly lower levels of DNMT1 mRNA expression (P<0.01) and significantly higher levels of MBD2 mRNA compared with the controls (P<0.01). DNA methylation was decreased following UVB irradiation at two different dosages and the DNA methylation levels of the patients with active SLE were more sensitive to UVB. The level of DNMT1 mRNA was decreased following UVB irradiation at the higher dosage in the patients with active SLE, but no significant difference was observed in MBD2 mRNA expression. UVB exposure is able to inhibit DNA methylation and DNMT1 mRNA expression, which is subsequently involved in the epigenetic mechanism of SLE. The process by which DNA hypomethylation occurs in patients with SLE is complicated and the multiple factors that are involved in DNA methylation and demethylation events require further study.
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