ArticleFrontiers in plant science2013
A nuclear localization for Avr2 from Fusarium oxysporum is required to activate the tomato resistance protein I-2.
Article in Frontiers in plant science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 59 citations in OpenAlex.
- Solanaceous vegetables andHorticulture research · 2026Article
- Lysine crotonylation enhances fungal effector activity and promotes invasion of host plants.Plant communications · 2026Article
- Glycoside Hydrolase CaGH17-12 Contributes to Phytophthora Blight Resistance by Activating the Production of Reactive Oxygen Species and Jasmonic Acid Signalling in Pepper.Molecular plant pathology · 2026Article
- Specific members of the TOPLESS family are susceptibility genes for Fusarium wilt in tomato and Arabidopsis.Plant biotechnology journal · 2024Article
- TomatoFrontiers in plant science · 2024Article
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- The warfare for plant highway: vascular plant-microbe interaction pinpoints lignin.Stress biology · 2022Article
- Pathogen effectors: What do they do at plasmodesmata?Molecular plant pathology · 2022Review
- Verticillium dahliae secreted protein Vd424Y is required for full virulence, targets the nucleus of plant cells, and induces cell death.Molecular plant pathology · 2021Article
- Secreted in Xylem Genes: Drivers of Host Adaptation inFrontiers in plant science · 2021Review
- The root-invading pathogen Fusarium oxysporum targets pattern-triggered immunity using both cytoplasmic and apoplastic effectors.The New phytologist · 2020Article
- TaTLP1 interacts with TaPR1 to contribute to wheat defense responses to leaf rust fungus.PLoS genetics · 2020Article
- Receptor-Like Kinases BAK1 and SOBIR1 Are Required for Necrotizing Activity of a Novel Group ofFrontiers in plant science · 2020Article
- Evidence for horizontal gene transfer and separation of effector recognition from effector function revealed by analysis of effector genes shared between cape gooseberry- and tomato-infecting formae speciales of Fusarium oxysporum.Molecular plant pathology · 2018Article
- Investigation of the diversity of effector genes in the banana pathogen, Fusarium oxysporum f. sp. cubense, reveals evidence of horizontal gene transfer.Molecular plant pathology · 2018Article
- Xylem Sap Proteomics Reveals Distinct Differences BetweenFrontiers in microbiology · 2018Article
- Structure-function analysis of the Fusarium oxysporum Avr2 effector allows uncoupling of its immune-suppressing activity from recognition.The New phytologist · 2017Article
- A mobile pathogenicity chromosome in Fusarium oxysporum for infection of multiple cucurbit species.Scientific reports · 2017Article
- LOCALIZER: subcellular localization prediction of both plant and effector proteins in the plant cell.Scientific reports · 2017Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant pathogens secrete effector proteins to promote host colonization. During infection of tomato xylem vessels, Fusarium oxysporum f. sp. lycopersici (Fol) secretes the Avr2 effector protein. Besides being a virulence factor, Avr2 is recognized intracellularly by the tomato I-2 resistance protein, resulting in the induction of host defenses. Here, we show that AVR2 is highly expressed in root- and xylem-colonizing hyphae three days post inoculation of roots. Co-expression of I-2 with AVR2 deletion constructs using agroinfiltration in Nicotiana benthamiana leaves revealed that, except for the N-terminal 17 amino acids, the entire AVR2 protein is required to trigger I-2-mediated cell death. The truncated Avr2 variants are still able to form homo-dimers, showing that the central region of Avr2 is required for dimerization. Simultaneous production of I-2 and Avr2 chimeras carrying various subcellular localization signals in N. benthamiana leaves revealed that a nuclear localization of Avr2 is required to trigger I-2-dependent cell death. Nuclear exclusion of Avr2 prevented its activation of I-2, suggesting that Avr2 is recognized by I-2 in the nucleus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.