ArticleFrontiers in systems neuroscience2013
An experimental method to identify neurogenic and myogenic active mechanical states of intestinal motility.
Article in Frontiers in systems neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Defining lower esophageal sphincter physiomechanical states among esophageal motility disorders using functional lumen imaging probe panometry.Neurogastroenterology and motility · 2024Article
- Faster Gastrointestinal Transit, Reduced Small Intestinal Smooth Muscle Tone and Dysmotility in theInternational journal of molecular sciences · 2024Article
- Causes and consequences: development and pathophysiology of Hirschsprung disease.World journal of pediatric surgery · 2024Review
- Relationship Between Intestinal Slow-waves, Spike-bursts, and Motility, as Defined Through High-resolution Electrical and Video Mapping.Journal of neurogastroenterology and motility · 2022Article
- First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques.Nature reviews. Gastroenterology & hepatology · 2019Review
- Inflammation-associated changes in DOR expression and function in the mouse colon.American journal of physiology. Gastrointestinal and liver physiology · 2018Article
- Image velocimetry and spectral analysis enable quantitative characterization of larval zebrafish gut motility.Neurogastroenterology and motility · 2018Article
- Quantifying Patterns of Smooth Muscle Motility in the Gut and Other Organs With New Techniques of Video Spatiotemporal Mapping.Frontiers in physiology · 2018Article
- Insights into the mechanisms underlying colonic motor patterns.The Journal of physiology · 2016Review
- Predicting the activation states of the muscles governing upper esophageal sphincter relaxation and opening.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Esophageal diverticula are associated with propagating peristalsis: a study utilizing high-resolution manometry.Neurogastroenterology and motility · 2016Article
- Spatiotemporal Mapping of Motility in Ex Vivo Preparations of the Intestines.Journal of visualized experiments : JoVE · 2016Article
- Characterization of Esophageal Physiology Using Mechanical State Analysis.Frontiers in systems neuroscience · 2016Article
- Motility patterns of ex vivo intestine segments depend on perfusion mode.World journal of gastroenterology · 2014Article
- The short chain fatty acids, butyrate and propionate, have differential effects on the motility of the guinea pig colon.Neurogastroenterology and motility · 2014Article
- Quantification of in vivo colonic motor patterns in healthy humans before and after a meal revealed by high-resolution fiber-optic manometry.Neurogastroenterology and motility · 2014Article
- Impedance as an adjunct to manometric testing to investigate symptoms of dysphagia: What it has failed to do and what it may tell us in the future.United European gastroenterology journal · 2014Review
- The four phases of esophageal bolus transit defined by high-resolution impedance manometry and fluoroscopy.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Esophageal distension during bolus transport: can it be detected by intraluminal impedance recordings?Neurogastroenterology and motility · 2014Article
- Upper esophageal sphincter mechanical states analysis: a novel methodology to describe UES relaxation and opening.Frontiers in systems neuroscience · 2014Article
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7 authors.
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Abstract
Excitatory and inhibitory enteric neural input to intestinal muscle acting on ongoing myogenic activity determines the rich repertoire of motor patterns involved in digestive function. The enteric neural activity cannot yet be established during movement of intact intestine in vivo or in vitro. We propose the hypothesis that is possible to deduce indirectly, but reliably, the state of activation of the enteric neural input to the muscle from measurements of the mechanical state of the intestinal muscle. The fundamental biomechanical model on which our hypothesis is based is the "three-element model" proposed by Hill. Our strategy is based on simultaneous video recording of changes in diameters and intraluminal pressure with a fiber-optic manometry in isolated segments of rabbit colon. We created a composite spatiotemporal map (DPMap) from diameter (DMap) and pressure changes (PMaps). In this composite map rhythmic myogenic motor patterns can readily be distinguished from the distension induced neural peristaltic contractions. Plotting the diameter changes against corresponding pressure changes at each location of the segment, generates "orbits" that represent the state of the muscle according to its ability to contract or relax actively or undergoing passive changes. With a software developed in MatLab, we identified twelve possible discrete mechanical states and plotted them showing where the intestine actively contracted and relaxed isometrically, auxotonically or isotonically, as well as where passive changes occurred or was quiescent. Clustering all discrete active contractions and relaxations states generated for the first time a spatio-temporal map of where enteric excitatory and inhibitory neural input to the muscle occurs during physiological movements. Recording internal diameter by an impedance probe proved equivalent to measuring external diameter, making possible to further develop similar strategy in vivo and humans.
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