ArticleFrontiers in cellular neuroscience2013
MicroRNAs and intellectual disability (ID) in Down syndrome, X-linked ID, and Fragile X syndrome.
Article in Frontiers in cellular neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Overexpression of miR-25 Downregulates the Expression of ROBO2 in Idiopathic Intellectual Disability.International journal of molecular sciences · 2024Article
- Deciphering the role of precursor miR-12136 and miR-8485 in the progression of intellectual disability (ID).IBRO neuroscience reports · 2022Article
- Aging with Down Syndrome-Where Are We Now and Where Are We Going?Journal of clinical medicine · 2021Review
- The Potential Role of miRNAs as Predictive Biomarkers in Neurodevelopmental Disorders.Journal of molecular neuroscience : MN · 2021Review
- The Epigenome in Neurodevelopmental Disorders.Frontiers in neuroscience · 2021Review
- Bioinformatics Analysis Revealed Novel 3'UTR Variants Associated with Intellectual Disability.Genes · 2020Article
- Genome-wide miRNA profiling in plasma of pregnant women with down syndrome fetuses.Molecular biology reports · 2020Article
- Is heart disease a risk factor for low dementia test battery scores in older persons with Down syndrome? Exploratory, pilot study, and commentary.International journal of developmental disabilities · 2020Article
- c[RGDyk]-coated liposomes loaded with adriamycin and miR-21 mimics inhibit the growth of hepatoma cell line SMCC-7721 via up-regulating Bax and p53.Translational cancer research · 2019Article
- Dysregulated CaFrontiers in synaptic neuroscience · 2019Review
- Neonatal anesthesia exposure impacts brain microRNAs and their associated neurodevelopmental processes.Scientific reports · 2018Article
- Integrative analyses of genes and microRNA expressions in human trisomy 21 placentas.BMC medical genomics · 2018Article
- Chromosome 21-Encoded microRNAs (mRNAs): Impact on Down's Syndrome and Trisomy-21 Linked Disease.Cellular and molecular neurobiology · 2018Article
- Profiling of Argonaute-2-loaded microRNAs in a mouse model of frontotemporal dementia with parkinsonism-17.International journal of physiology, pathophysiology and pharmacology · 2018Article
- Down syndrome and microRNAs.Biomedical reports · 2018Article
- Decreased miRNA expression in Klinefelter syndrome.Scientific reports · 2017Article
- A microRNA cluster (let-7c, miRNA-99a, miRNA-125b, miRNA-155 and miRNA-802) encoded at chr21q21.1-chr21q21.3 and the phenotypic diversity of Down's syndrome (DS; trisomy 21).Journal of nature and science · 2017Article
- Spatiotemporal Expression and Molecular Characterization of miR-344b and miR-344c in the Developing Mouse Brain.Neural plasticity · 2016Article
- Cerebralcare Granule® attenuates cognitive impairment in rats continuously overexpressing microRNA-30e.Molecular medicine reports · 2015Article
- MicroRNAs as potential biomarkers for noninvasive detection of fetal trisomy 21.Journal of assisted reproduction and genetics · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intellectual disability (ID) is one of the many features manifested in various genetic syndromes leading to deficits in cognitive function among affected individuals. ID is a feature affected by polygenes and multiple environmental factors. It leads to a broad spectrum of affected clinical and behavioral characteristics among patients. Until now, the causative mechanism of ID is unknown and the progression of the condition is poorly understood. Advancement in technology and research had identified various genetic abnormalities and defects as the potential cause of ID. However, the link between these abnormalities with ID is remained inconclusive and the roles of many newly discovered genetic components such as non-coding RNAs have not been thoroughly investigated. In this review, we aim to consolidate and assimilate the latest development and findings on a class of small non-coding RNAs known as microRNAs (miRNAs) involvement in ID development and progression with special focus on Down syndrome (DS) and X-linked ID (XLID) [including Fragile X syndrome (FXS)].
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.