ArticleFrontiers in cellular neuroscience2013
Large-scale synchronized activity in the embryonic brainstem and spinal cord.
Article in Frontiers in cellular neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- When does consciousness arise? A subcortical model of its origins.Brain structure & function · 2026Review
- Epigenetic and Transcriptional Regulation of Spontaneous and Sensory Activity Dependent Programs During Neuronal Circuit Development.Frontiers in neural circuits · 2022Review
- Article
- Prenatal exposure to nicotine disrupts synaptic network formation by inhibiting spontaneous correlated wave activity.IBRO reports · 2020Article
- Muscles of Breathing: Development, Function, and Patterns of Activation.Comprehensive Physiology · 2019Review
- Maturation of Breathing-Related Inhibitory Neurotransmission in the Medulla Oblongata of the Embryonic and Perinatal Zebra Finch (Taeniopygia guttata).Developmental neurobiology · 2018Article
- GABA and Gap Junctions in the Development of Synchronized Activity in Human Pluripotent Stem Cell-Derived Neural Networks.Frontiers in cellular neuroscience · 2018Article
- Clustered Protocadherins Are Required for Building Functional Neural Circuits.Frontiers in molecular neuroscience · 2017Article
- Functiogenesis of the embryonic central nervous system revealed by optical recording with a voltage-sensitive dye.The journal of physiological sciences : JPS · 2017Review
- Activity-dependent plasticity in the isolated embryonic avian brainstem following manipulations of rhythmic spontaneous neural activity.Respiratory physiology & neurobiology · 2016Article
- Studying respiratory rhythm generation in a developing bird: Hatching a new experimental model using the classic in vitro brainstem-spinal cord preparation.Respiratory physiology & neurobiology · 2016Article
- Tonic nicotinic transmission enhances spinal GABAergic presynaptic release and the frequency of spontaneous network activity.Developmental neurobiology · 2016Article
- Development of Spontaneous Activity in the Avian Hindbrain.Frontiers in neural circuits · 2016Review
- Perchance to dream? Primordial motor activity patterns in vertebrates from fish to mammals: their prenatal origin, postnatal persistence during sleep, and pathological reemergence during REM sleep behavior disorder.Neuroscience bulletin · 2015Review
- Voltage-sensitive dye imaging during functional development of the embryonic nervous system: a brief review with special thanks to Professor Larry Cohen.Neurophotonics · 2015Review
- Review
- Evaluation of voltage-sensitive fluorescence dyes for monitoring neuronal activity in the embryonic central nervous system.The Journal of membrane biology · 2013Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the developing central nervous system, spontaneous activity appears well before the brain responds to external sensory inputs. One of the earliest activities is observed in the hindbrain and spinal cord, which is detected as rhythmic electrical discharges of cranial and spinal motoneurons or oscillations of Ca(2+)- and voltage-related optical signals. Shortly after the initial expression, the spontaneous activity appearing in the hindbrain and spinal cord exhibits a large-scale correlated wave that propagates over a wide region of the central nervous system, maximally extending to the lumbosacral cord and to the forebrain. In this review, we describe several aspects of this synchronized activity by focusing on the basic properties, development, origin, propagation pattern, pharmacological characteristics, and possible mechanisms underlying the generation of the activity. These profiles differ from those of the respiratory and locomotion pattern generators observed in the mature brainstem and spinal cord, suggesting that the wave is primordial activity that appears during a specific period of embryonic development and plays some important roles in the development of the central nervous system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.