ArticleFrontiers in molecular neuroscience2013
Circadian clocks and memory: time-place learning.
Article in Frontiers in molecular neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 63 citations in OpenAlex.
- Multiple oscillators underlie circadian food anticipation in mice.Neurobiology of sleep and circadian rhythms · 2025Article
- Longitudinal Evaluation of the Detection Potential of Serum Oligoelements Cu, Se and Zn for the Diagnosis of Alzheimer's Disease in the 3xTg-AD Animal Model.International journal of molecular sciences · 2025Article
- Circadian system and aging: where both times interact.Frontiers in aging · 2025Review
- Bumble Bees (Insects · 2023Article
- Cavefishes in Chronobiological Research: A Narrative Review.Clocks & sleep · 2023Review
- Challenges and advanced concepts for the assessment of learning and memory function in mice.Frontiers in behavioral neuroscience · 2023Review
- Multiple entrained oscillator model of food anticipatory circadian rhythms.Scientific reports · 2022Article
- Influence of diurnal phase on behavioral tests of sensorimotor performance, anxiety, learning and memory in mice.Scientific reports · 2022Article
- Heliconiini butterflies can learn time-dependent reward associations.Biology letters · 2020Article
- Model and Non-model Insects in Chronobiology.Frontiers in behavioral neuroscience · 2020Review
- Translational Difficulties in Querying Rats on "Orientation".BioMed research international · 2019Article
- Modulation of learning and memory by the genetic disruption of circadian oscillator populations.Physiology & behavior · 2018Article
- Time is honey: circadian clocks of bees and flowers and how their interactions may influence ecological communities.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Effects of aging on circadian patterns of gene expression in the human prefrontal cortex.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Time-place learning over a lifetime: absence of memory loss in trained old mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- Role of Aging and Hippocampus in Time-Place Learning: Link to Episodic-Like Memory?Frontiers in behavioral neuroscience · 2015Article
- Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration.Frontiers in neuroscience · 2015Review
- Neither the SCN nor the adrenals are required for circadian time-place learning in mice.Chronobiology international · 2014Article
- Article
- A time to remember: the role of circadian clocks in learning and memory.Behavioral neuroscience · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Time-Place learning (TPL) refers to the ability of animals to remember important events that vary in both time and place. This ability is thought to be functional to optimize resource localization and predator avoidance in a circadian changing environment. Various studies have indicated that animals use their circadian system for TPL. However, not much is known about this specific role of the circadian system in cognition. This review aims to put TPL in a broader context and to provide an overview of historical background, functional aspects, and future perspectives of TPL. Recent advances have increased our knowledge on establishing TPL in a laboratory setting, leading to the development of a behavioral paradigm demonstrating the circadian nature of TPL in mice. This has enabled the investigation of circadian clock components on a functional behavioral level. Circadian TPL (cTPL) was found to be Cry clock gene dependent, confirming the essential role of Cry genes in circadian rhythms. In contrast, preliminary results have shown that cTPL is independent of Per genes. Circadian system decline with aging predicts that cTPL is age sensitive, potentially qualifying TPL as a functional model for episodic memory and aging. The underlying neurobiological mechanism of TPL awaits further examination. Here we discuss some putative mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.