ArticleFrontiers in neuroscience2013
Review: regulatory mechanisms of gonadotropin-inhibitory hormone (GnIH) synthesis and release in photoperiodic animals.
Article in Frontiers in neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 111 citations in OpenAlex.
- Changes in Ovarian Activity and Expressions of Follicle Development Regulation Factors During the Laying-Incubation Cycle in Magang Geese.Animals : an open access journal from MDPI · 2025Article
- Photoperiod Management in Farm Animal Husbandry: A Review.Animals : an open access journal from MDPI · 2025Review
- Review
- Article
- Photoperiodic physiology of summer breeding birds and a search for the role of eye.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024Review
- Effects of Blue Light on Puberty and Ovary in Female RatsJournal of clinical research in pediatric endocrinology · 2023Article
- Metabolic Changes During Growth and Reproductive Phases in the Liver of Female Goldfish (Carassius auratus).Frontiers in cell and developmental biology · 2022Article
- Photoperiod affects the laying performance of the mountain duck by regulating endocrine hormones and gene expression.Veterinary medicine and science · 2021Article
- RF-amide related peptide-3 (RFRP-3): a novel neuroendocrine regulator of energy homeostasis, metabolism, and reproduction.Molecular biology reports · 2021Review
- The Role of GnIH in Biological Rhythms and Social Behaviors.Frontiers in endocrinology · 2021Review
- Molecular Mechanisms of Gonadotropin-Inhibitory Hormone (GnIH) Actions in Target Cells and Regulation of GnIH Expression.Frontiers in endocrinology · 2019Review
- The underlying mechanisms of vertebrate seasonal reproduction.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2019Review
- The Gonadotropin-Inhibitory Hormone: What We Know and What We Still Have to Learn From Fish.Frontiers in endocrinology · 2019Review
- Gonadotrophin-inhibitory hormone and its mammalian orthologue RFamide-related peptide-3: Discovery and functional implications for reproduction and stress.Journal of neuroendocrinology · 2018Review
- How to Contribute to the Progress of Neuroendocrinology: Discovery of GnIH and Progress of GnIH Research.Frontiers in endocrinology · 2018Review
- Neural Androgen Synthesis and Aggression: Insights From a Seasonally Breeding Rodent.Frontiers in endocrinology · 2018Review
- A Journey through the Gonadotropin-Inhibitory Hormone System of Fish.Frontiers in endocrinology · 2017Review
- Gonadotropin Inhibitory Hormone Down-Regulates the Brain-Pituitary Reproductive Axis of Male European Sea Bass (Dicentrarchus labrax).Biology of reproduction · 2016Article
- The ecological and physiological bases of variation in the phenology of gonad growth in an urban and desert songbird.General and comparative endocrinology · 2016Article
- The Role of Melatonin as a Hormone and an Antioxidant in the Control of Fish Reproduction.Frontiers in endocrinology · 2016Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Gonadotropin-inhibitory hormone (GnIH) is a novel hypothalamic neuropeptide that was discovered in quail as an inhibitory factor for gonadotropin release. GnIH inhibits gonadotropin synthesis and release in birds through actions on gonadotropin-releasing hormone (GnRH) neurons and gonadotropes, mediated via the GnIH receptor (GnIH-R), GPR147. Subsequently, GnIH was identified in mammals and other vertebrates. As in birds, mammalian GnIH inhibits gonadotropin secretion, indicating a conserved role for this neuropeptide in the control of the hypothalamic-pituitary-gonadal (HPG) axis across species. Identification of the regulatory mechanisms governing GnIH expression and release is important in understanding the physiological role of the GnIH system. A nocturnal hormone, melatonin, appears to act directly on GnIH neurons through its receptor to induce expression and release of GnIH in quail, a photoperiodic bird. Recently, a similar, but opposite, action of melatonin on the inhibition of expression of mammalian GnIH was shown in hamsters and sheep, photoperiodic mammals. These results in photoperiodic animals demonstrate that GnIH expression is photoperiodically modulated via a melatonin-dependent process. Recent findings indicate that GnIH may be a mediator of stress-induced reproductive disruption in birds and mammals, pointing to a broad role for this neuropeptide in assessing physiological state and modifying reproductive effort accordingly. This paper summarizes the advances made in our knowledge regarding the regulation of GnIH synthesis and release in photoperiodic birds and mammals. This paper also discusses the neuroendocrine integration of environmental signals, such as photoperiods and stress, and internal signals, such as GnIH, melatonin, and glucocorticoids, to control avian and mammalian reproduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.