ArticleFrontiers in neuroscience2013
Optogenetic approaches for functional mouse brain mapping.
Article in Frontiers in neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 56 citations in OpenAlex.
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- Multimodal Nature of the Single-cell Primate Brain Atlas: Morphology, Transcriptome, Electrophysiology, and Connectivity.Neuroscience bulletin · 2024Review
- Altered functional connectivity after pilocarpine-induced seizures revealed by intrinsic optical signals imaging in awake mice.Neurophotonics · 2024Article
- Tracking connectivity maps in human stem cell-derived neuronal networks by holographic optogenetics.Life science alliance · 2022Article
- Autonomic dysfunction in epilepsy mouse models with implications for SUDEP research.Frontiers in neurology · 2022Review
- Closed-loop neuromodulation will increase the utility of mouse models in Bioelectronic Medicine.Bioelectronic medicine · 2021Article
- Feasibility of cerium-doped LSO particles as a scintillator for x-ray induced optogenetics.Journal of neural engineering · 2021Article
- Optogenetic study of the response interaction among multi-afferent inputs in the barrel cortex of rats.Scientific reports · 2019Article
- NeuroMeasure: A Software Package for Quantification of Cortical Motor Maps Using Frameless Stereotaxic Transcranial Magnetic Stimulation.Frontiers in neuroinformatics · 2019Article
- LSO:Ce Inorganic Scintillators Are Biocompatible With Neuronal and Circuit Function.Frontiers in synaptic neuroscience · 2019Article
- Organization of the connections between claustrum and cortex in the mouse.The Journal of comparative neurology · 2017Article
- A soft, transparent, freely accessible cranial window for chronic imaging and electrophysiology.Scientific reports · 2016Article
- Article
- Optogenetic Approaches to Target Specific Neural Circuits in Post-stroke Recovery.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
- Brain Computation Is Organized via Power-of-Two-Based Permutation Logic.Frontiers in systems neuroscience · 2016Article
- Probing Neural Transplant Networks In Vivo with Optogenetics and Optogenetic fMRI.Stem cells international · 2016Review
- Optogenetic mapping after stroke reveals network-wide scaling of functional connections and heterogeneous recovery of the peri-infarct.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Mesoscale transcranial spontaneous activity mapping in GCaMP3 transgenic mice reveals extensive reciprocal connections between areas of somatomotor cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Genetic dissection of GABAergic neural circuits in mouse neocortex.Frontiers in cellular neuroscience · 2014Review
- Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To better understand the connectivity of the brain, it is important to map both structural and functional connections between neurons and cortical regions. In recent years, a set of optogenetic tools have been developed that permit selective manipulation and investigation of neural systems. These tools have enabled the mapping of functional connections between stimulated cortical targets and other brain regions. Advantages of the approach include the ability to arbitrarily stimulate brain regions that express opsins, allowing for brain mapping independent of behavior or sensory processing. The ability of opsins to be rapidly and locally activated allows for investigation of connectivity with spatial resolution on the order of single neurons and temporal resolution on the order of milliseconds. Optogenetic methods for functional mapping have been applied in experiments ranging from in vitro investigation of microcircuits, to in vivo probing of inter-regional cortical connections, to examination of global connections within the whole brain. We review recently developed functional mapping methods that use optogenetic single-point stimulation in the rodent brain and employ cellular electrophysiology, evoked motor movements, voltage sensitive dyes (VSDs), calcium indicators, or functional magnetic resonance imaging (fMRI) to assess activity. In particular we highlight results using red-shifted organic VSDs that permit high temporal resolution imaging in a manner spectrally separated from Channelrhodopsin-2 (ChR2) activation. VSD maps stimulated by ChR2 were dependent on intracortical synaptic activity and were able to reflect circuits used for sensory processing. Although the methods reviewed are powerful, challenges remain with respect to finding approaches that permit selective high temporal resolution assessment of stimulated activity in animals that can be followed longitudinally.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.