ArticleJournal of neurophysiology2013
Spontaneous and sensory-evoked activity in mouse olfactory sensory neurons with defined odorant receptors.
Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 62 citations in OpenAlex.
- Intrinsic Diversity in Odor-Evoked Calcium Rises acrossThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Glomerulus-Specific Inhomogeneity of the Basal Activity Map in the Olfactory Bulb.International journal of molecular sciences · 2026Article
- Immature olfactory sensory neurons are intrinsically excitable and show maturation-dependent changes in voltage-gated NaPflugers Archiv : European journal of physiology · 2026Article
- Constancy of olfactory cilia in rodents.Chemical senses · 2025Article
- Epigenetic programming of stochastic olfactory receptor choice.Genesis (New York, N.Y. : 2000) · 2024Review
- Influence of age on nicotinic cholinergic regulation of blood flow in rat's olfactory bulb and neocortex.The journal of physiological sciences : JPS · 2024Review
- Activity-dependent formation of the topographic map and the critical period in the development of mammalian olfactory system.Genesis (New York, N.Y. : 2000) · 2024Review
- Shedding light on human olfaction: Electrophysiological recordings from sensory neurons in acute slices of olfactory epithelium.iScience · 2023Article
- Depolarization block in olfactory sensory neurons expands the dimensionality of odor encoding.Science advances · 2022Article
- Developing and maintaining a nose-to-brain map of odorant identity.Open biology · 2022Review
- Epigenetic and Transcriptional Regulation of Spontaneous and Sensory Activity Dependent Programs During Neuronal Circuit Development.Frontiers in neural circuits · 2022Review
- Longitudinal imaging of individual olfactory sensory neuronsFrontiers in cellular neuroscience · 2022Article
- The role of the odorant receptors in the formation of the sensory map.BMC biology · 2021Review
- Resolving different presynaptic activity patterns within single olfactory glomeruli of Xenopus laevis larvae.Scientific reports · 2021Article
- Article
- Topographic organization in the olfactory bulb.Cell and tissue research · 2021Review
- The functional relevance of olfactory marker protein in the vertebrate olfactory system: a never-ending story.Cell and tissue research · 2021Review
- Spontaneous Afferent Activity Carves Olfactory Circuits.Frontiers in cellular neuroscience · 2021Article
- Sensory Transduction in Photoreceptors and Olfactory Sensory Neurons: Common Features and Distinct Characteristics.Frontiers in cellular neuroscience · 2021Review
- Effects of nicotine on regional blood flow in the olfactory bulb in response to olfactory nerve stimulation.The journal of physiological sciences : JPS · 2020Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
Sensory systems need to tease out stimulation-evoked activity against a noisy background. In the olfactory system, the odor response profile of an olfactory sensory neuron (OSN) is dependent on the type of odorant receptor it expresses. OSNs also exhibit spontaneous activity, which plays a role in establishing proper synaptic connections and may also increase the sensitivity of the cells. However, where the spontaneous activity originates and whether it informs sensory-evoked activity remain unclear. We addressed these questions by examining patch-clamp recordings of genetically labeled mouse OSNs with defined odorant receptors in intact olfactory epithelia. We show that OSNs expressing different odorant receptors had significantly different rates of basal activity. Additionally, OSNs expressing an inactive mutant I7 receptor completely lacked spontaneous activity, despite being able to fire action potentials in response to current injection. This finding strongly suggests that the spontaneous firing of an OSN originates from the spontaneous activation of its G protein-coupled odorant receptor. Moreover, OSNs expressing the same receptor displayed considerable variation in their spontaneous activity, and the variation was broadened upon odor stimulation. Interestingly, there is no significant correlation between the spontaneous and sensory-evoked activity in these neurons. This study reveals that the odorant receptor type determines the spontaneous firing rate of OSNs, but the basal activity does not correlate with the activity induced by near-saturated odor stimulation. The implications of these findings on olfactory information processing are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.