Evidence map›Paper›PMID 23596180›Full record

ArticleDiabetes care2013

Evidence of reduced β-cell function in Asian Indians with mild dysglycemia.

Lisa R Staimez, Mary Beth Weber, Harish Ranjani, Mohammed K Ali, Justin B Echouffo-Tcheugui, Lawrence S Phillips, Viswanathan Mohan, K M Venkat Narayan

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01283308 (The Diabetes Community Lifestyle Improvement Program), which is not on this map. Cited by 53 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 2 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01283308 nacompletednot on this map

The Diabetes Community Lifestyle Improvement Program (D-CLIP): A Translation Randomized Trial of a Culturally Specific Lifestyle Intervention for Diabetes Prevention in India

TypeinterventionalSponsorEmory UniversityRan2009 to 2013Enrolled599ConditionsDiabetes Mellitus, Type 2ArmsLifestyle Intervention, Standard of Care
3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 125 citations in OpenAlex.

  1. Pooled it
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  11. Phenotypic and Genetic Diversity in Diabetes Across Populations.The Journal of clinical endocrinology and metabolism · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Lisa R StaimezNutrition and Health Sciences Program, Graduate Division of Biomedical and Biological Sciences, Laney Graduate School, Emory University, Atlanta, Georgia, USA. lisa.staimez@emory.edu
Mary Beth Weber
Harish Ranjani
Mohammed K Ali
Justin B Echouffo-Tcheugui
Lawrence S Phillips
Viswanathan Mohan
K M Venkat Narayan
Emory University · USMadras Diabetes Research Foundation · IN

Funding

ENDOCRINOLOGY, METABOLISM, AND DIABETEST32DK007298 · NIDDK · EMORY UNIVERSITY · PI PACIFICI, ROBERTO · 1986 to 2014
$3.2M
Nutrition Sciences and HealthT32DK007734 · NIDDK · EMORY UNIVERSITY · PI RAMAKRISHNAN, USHA · 1997 to 2016
$2.5M
NIDDK NIH HHS 5T32DK007298-33NIDDK NIH HHS T32 DK007298NIDDK NIH HHS T32 DK007734
6 · The paper itself

Abstract

objectiveTo examine β-cell function across a spectrum of glycemia among Asian Indians, a population experiencing type 2 diabetes development at young ages despite low BMI. RESEARCH DESIGN AND

methodsOne-thousand two-hundred sixty-four individuals without known diabetes in the Diabetes Community Lifestyle Improvement Program in Chennai, India, had a 75-g oral glucose tolerance test, with glucose and insulin measured at 0, 30, and 120 min. Type 2 diabetes, isolated impaired fasting glucose (iIFG), isolated impaired glucose tolerance (iIGT), combined impaired fasting glucose and impaired glucose tolerance, and normal glucose tolerance (NGT) were defined by American Diabetes Association guidelines. Measures included insulin resistance and sensitivity (homeostasis model assessment of insulin resistance [HOMA-IR], modified Matsuda Index, 1/fasting insulin) and β-cell function (oral disposition index = [Δ insulin0-30/Δ glucose 0-30] × [1/fasting insulin]).

resultsMean age was 44.2 years (SD, 9.3) and BMI 27.4 kg/m(2) (SD, 3.8); 341 individuals had NGT, 672 had iIFG, IGT, or IFG plus IGT, and 251 had diabetes. Patterns of insulin resistance or sensitivity were similar across glycemic categories. With mild dysglycemia, the absolute differences in age- and sex-adjusted oral disposition index (NGT vs. iIFG, 38%; NGT vs. iIGT, 32%) were greater than the differences in HOMA-IR (NGT vs. iIFG, 25%; NGT vs. iIGT, 23%; each P < 0.0001). Compared with NGT and adjusted for age, sex, BMI, waist circumference, and family history, the odds of mild dysglycemia were more significant per SD of oral disposition index (iIFG: odds ratio [OR], 0.36; 95% CI, 0.23-0.55; iIGT: OR, 0.37; 95% CI, 0.24-0.56) than per SD of HOMA-IR (iIFG: OR, 1.69; 95% CI, 1.23-2.33; iIGT: OR, 1.53; 95% CI, 1.11-2.11).

conclusionsAsian Indians with mild dysglycemia have reduced β-cell function, regardless of age, adiposity, insulin sensitivity, or family history. Strategies in diabetes prevention should minimize loss of β-cell function.

Indexed as

AdiposityAdultAsian PeopleBlood GlucoseDiabetes Mellitus, Type 2FemaleGlucose IntoleranceGlucose Tolerance TestHumansIndiaInsulin-Secreting CellsMaleBlood Glucose

Identifiers

PMID23596180
PMCPMC3747932
OpenAlexW2065579752

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.