ReviewInternational archives of occupational and environmental health2014
Allergens causing occupational asthma: an evidence-based evaluation of the literature.
Review in International archives of occupational and environmental health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- A systematic review of the relation between ten potential occupational sensitizing exposures and asthma.Scandinavian journal of work, environment & health · 2025Pooled it
- Complex Substrates and Bedding for Environmental Enhancement and Research: Or, the Nature of Primates.American journal of primatology · 2026Review
- Bridging Clinical and Chemical Research in Occupational Asthma.Current medicinal chemistry · 2026Article
- Bridging Gaps in Occupational Respiratory Disease Management: A Comparative Survey of Pulmonologists and Occupational Physicians in Italy.Clinics and practice · 2025Article
- Review
- Contact Urticaria and Related Conditions: Clinical Review.Contact dermatitis · 2025Review
- Occupational exposure and its mechanistic link to allergic asthma and lung function decline; a data-driven approach coupled to mining of adverse outcome pathway signatures.Frontiers in toxicology · 2025Article
- Pesticides impacts on human health and the environment with their mechanisms of action and possible countermeasures.Heliyon · 2024Review
- Prevalence and predictors of occupational asthma among workers in detergent and cleaning products industry and its impact on quality of life in El Asher Men Ramadan, Egypt.Environmental science and pollution research international · 2022Article
- Comparing the concentration levels of allergens and endotoxins in employees' homes and offices.International archives of occupational and environmental health · 2022Article
- The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?International journal of environmental research and public health · 2021Review
- Scoping Review-The Association between Asthma and Environmental Chemicals.International journal of environmental research and public health · 2021Article
- Parental occupational exposure pre- and post-conception and development of asthma in offspring.International journal of epidemiology · 2021Article
- Assessment of the effects of a work-related allergy to seafood on the reduction of earning capacity in the context of BK No. 5101.Allergologie select · 2021Review
- Work-related asthma: A position paper from the Thoracic Society of Australia and New Zealand and the National Asthma Council Australia.Respirology (Carlton, Vic.) · 2020Review
- Skin Exposure Contributes to Chemical-Induced Asthma: What is the Evidence? A Systematic Review of Animal Models.Allergy, asthma & immunology research · 2020Review
- Review
- Update on the Management of Occupational Asthma and Work-Exacerbated Asthma.Allergy, asthma & immunology research · 2019Review
- Epidemiology of Asthma in Children and Adults.Frontiers in pediatrics · 2019Review
- Skin and respiratory chemical allergy: confluence and divergence in a hybrid adverse outcome pathway.Toxicology research · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this work is to provide an evidence-based evaluation and overview of causative substances in order to improve disease management.
methodsWe conducted a database search with MEDLINE via PubMed, screened reference lists of relevant reviews and matched our findings with a list of agents denoted as "may cause sensitisation by inhalation" by the phrase H334 (till 2011 R42). After exclusion of inappropriate publications, quality of the selected studies was rated with the Scottish Intercollegiate Guideline Network (SIGN) grading system. The evidence level for each causative agent was graded using the modified Royal College of General Practitioners (RCGP) three-star system.
resultsA total of 865 relevant papers were identified, which covered 372 different causes of allergic work-related asthma. The highest level achieved using the SIGN grading system was 2++ indicating a high-quality study with a very low risk of confounding or bias and a high probability of a causal relationship. According to the modified RCGP three-star grading system, the strongest evidence of association with an individual agent, profession or worksite ("***") was found to be the co-exposure to various laboratory animals. An association with moderate evidence level ("**") was obtained for α-amylase from Aspergillus oryzae, various enzymes from Bacillus subtilis, papain, bakery (flour, amylase, storage mites), western red cedar, latex, psyllium, farming (animals, cereal, hay, straw and storage mites), storage mites, rat, carmine, egg proteins, atlantic salmon, fishmeal, norway lobster, prawn, snow crab, seafood, trout and turbot, reactive dyes, toluene diisocyanates and platinum salts.
conclusionThis work comprises the largest list of occupational agents and worksites causing allergic asthma. For the first time, these agents are assessed in an evidence-based manner. The identified respiratory allergic agents or worksites with at least moderate evidence for causing work-related asthma may help primary care physicians and occupational physicians in diagnostics and management of cases suffering from work-related asthma. Furthermore, this work may possibly provide a major contribution to prevention and may also initiate more detailed investigations for broadening and updating these evidence-based evaluations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.