ArticleJournal of biomedical optics2013
Fluorescence lifetime imaging and reflectance confocal microscopy for multiscale imaging of oral precancer.
Article in Journal of biomedical optics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 51 citations in OpenAlex.
- Ultrafast optical imaging techniques for exploring rapid neuronal dynamics.Neurophotonics · 2025Review
- Dual excitation spectral autofluorescence lifetime and reflectance imaging for fast macroscopic characterization of tissues.Biomedical optics express · 2024Article
- Development of a multimodal mobile colposcope for real-time cervical cancer detection.Biomedical optics express · 2022Article
- Fast volumetric imaging with line-scan confocal microscopy by electrically tunable lens at resonant frequency.Optics express · 2022Article
- Label-free sensing of cells with fluorescence lifetime imaging: The quest for metabolic heterogeneity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Blind deconvolution estimation by multi-exponential models and alternated least squares approximations: Free-form and sparse approach.PloS one · 2021Article
- Multimodal widefield fluorescence imaging with nonlinear optical microscopy workflow for noninvasive oral epithelial neoplasia detection: a preclinical study.Journal of biomedical optics · 2020Article
- Optical Biopsy of the Upper GI Tract Using Fluorescence Lifetime and Spectra.Frontiers in physiology · 2020Article
- Extended Blind End-member and Abundance Extraction for Biomedical Imaging Applications.IEEE access : practical innovations, open solutions · 2019Article
- Real-time visualization of two-photon fluorescence lifetime imaging microscopy using a wavelength-tunable femtosecond pulsed laser.Biomedical optics express · 2018Article
- Multispectral analog-mean-delay fluorescence lifetime imaging combined with optical coherence tomography.Biomedical optics express · 2018Article
- Review of quantitative multiscale imaging of breast cancer.Journal of medical imaging (Bellingham, Wash.) · 2018Review
- Non-invasive intravital imaging of head and neck squamous cell carcinomas in live mice.Methods (San Diego, Calif.) · 2017Article
- Development of a multimodal foveated endomicroscope for the detection of oral cancer.Biomedical optics express · 2017Article
- Optical techniques for cervical neoplasia detection.Beilstein journal of nanotechnology · 2017Review
- Multimodal optical coherence tomography and fluorescence lifetime imaging with interleaved excitation sources for simultaneous endogenous and exogenous fluorescence.Biomedical optics express · 2016Article
- Objective Detection of Oral Carcinoma with Multispectral Fluorescence Lifetime Imaging In Vivo.Photochemistry and photobiology · 2016Article
- A novel multimodal optical imaging system for early detection of oral cancer.Oral surgery, oral medicine, oral pathology and oral radiology · 2016Article
- Quadratic blind linear unmixing: A graphical user interface for tissue characterization.Computer methods and programs in biomedicine · 2016Article
- Deconvolution of fluorescence lifetime imaging microscopy by a library of exponentials.Optics express · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Optical imaging techniques using a variety of contrast mechanisms are under evaluation for early detection of epithelial precancer; however, tradeoffs in field of view (FOV) and resolution may limit their application. Therefore, we present a multiscale multimodal optical imaging system combining macroscopic biochemical imaging of fluorescence lifetime imaging (FLIM) with subcellular morphologic imaging of reflectance confocal microscopy (RCM). The FLIM module images a 16×16 mm² tissue area with 62.5 μm lateral and 320 ps temporal resolution to guide cellular imaging of suspicious regions. Subsequently, coregistered RCM images are acquired at 7 Hz with 400 μm diameter FOV, <1 μm lateral and 3.5 μm axial resolution. FLIM-RCM imaging was performed on a tissue phantom, normal porcine buccal mucosa, and a hamster cheek pouch model of oral carcinogenesis. While FLIM is sensitive to biochemical and macroscopic architectural changes in tissue, RCM provides images of cell nuclear morphology, all key indicators of precancer progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.