ArticleHuman mutation2013
Prioritization of genetic variants in the microRNA regulome as functional candidates in genome-wide association studies.
Article in Human mutation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prospective associations of coronary heart disease loci in African Americans using the MetaboChip: the PAGE study.PloS one · 2014Pooled it
- Integrating Genes Affecting Coronary Artery Disease in Functional Networks by Multi-OMICs Approach.Frontiers in cardiovascular medicine · 2018Review
- Association of MiR-149 (RS2292832) Variant with the Risk of Coronary Artery Disease.Journal of medical biochemistry · 2017Article
- Mapping of microRNAs related to cervical cancer in Latin American human genomic variants.F1000Research · 2017Article
- Analysis of microRNA and Gene Expression Profiles in Multiple Sclerosis: Integrating Interaction Data to Uncover Regulatory Mechanisms.Scientific reports · 2016Article
- Genetic variants in regulatory regions of microRNAs are associated with lung cancer risk.Oncotarget · 2016Article
- SomamiR 2.0: a database of cancer somatic mutations altering microRNA-ceRNA interactions.Nucleic acids research · 2016Article
- A functional variant in miR-155 regulation region contributes to lung cancer risk and survival.Oncotarget · 2015Article
- Multiple conformations are a conserved and regulatory feature of the RB1 5' UTR.RNA (New York, N.Y.) · 2015Article
- SubmiRine: assessing variants in microRNA targets using clinical genomic data sets.Nucleic acids research · 2015Article
- ReMo-SNPs: a new software tool for identification of polymorphisms in regions and motifs genome-wide.Genetics research · 2015Article
- Genetic variability of microRNA regulome in human.Molecular genetics & genomic medicine · 2015Article
- Global population-specific variation in miRNA associated with cancer risk and clinical biomarkers.BMC medical genomics · 2014Article
- An integrated analysis of the SOX2 microRNA response program in human pluripotent and nullipotent stem cell lines.BMC genomics · 2014Article
- Proteogenomics of selective susceptibility to endotoxin using circulating acute phase biomarkers and bioassay development in sheep: a review.Proteome science · 2014Article
- PolymiRTS Database 3.0: linking polymorphisms in microRNAs and their target sites with human diseases and biological pathways.Nucleic acids research · 2014Article
- The potential of the riboSNitch in personalized medicine.Wiley interdisciplinary reviews. RNAReview
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Authors and funding
3 authors.
Funding
Abstract
Comprehensive analyses of results from genome-wide association studies (GWAS) have demonstrated that complex disease/trait-associated loci are enriched in gene regulatory regions of the genome. The search for causal regulatory variation has focused primarily on transcriptional elements, such as promoters and enhancers. microRNAs (miRNAs) are now widely appreciated as critical posttranscriptional regulators of gene expression and are thought to impart stability to biological systems. Naturally occurring genetic variation in the miRNA regulome is likely an important contributor to phenotypic variation in the human population. However, the extent to which polymorphic miRNA-mediated gene regulation underlies GWAS signals remains unclear. In this study, we have developed the most comprehensive bioinformatic analysis pipeline to date for cataloging and prioritizing variants in the miRNA regulome as functional candidates in GWAS. We highlight specific findings, including a variant in the promoter of the miRNA let-7 that may contribute to human height variation. We also provide a discussion of how our approach can be expanded in the future. Overall, we believe that the results of this study will be valuable for researchers interested in determining whether GWAS signals implicate the miRNA regulome in their disease/trait of interest.
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